The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors. In contrast to many other nuclear receptors, GR is thought to be exclusively cytoplasmic in quiescent cells, and only translocate to the nucleus on ligand binding. We now demonstrate significant nuclear GR in the absence of ligand, which requires nuclear localisati...

The scattering far zone for light transmitted through a sphere following p - 1 internal reflections by a family of near-grazing incident rays is subdivided into a lit region and a shadow region. The sharpness of the ray theory transition between the lit and the shadow regions is smoothed in wave theory by radiation shed by electromagnetic surface waves. It is shown that when higher-order terms ...

BACKGROUND Parathyroid hormone (PTH) is an effective anti-osteoporosis agent, after binding to its receptor PTHR1, several signaling pathways, including cAMP/protein kinase A (PKA) and phospholipase C (PLC)/protein kinase C (PKC), are initiated through G proteins; with the cAMP/PKA pathway as the major pathway. Earlier studies have reported that PTHR1 might also activate PKC via a PLC-independe...

BACKGROUND Cardiovascular calcification represents a marker of cardiovascular risk in chronic dialysis patients. In the general population, aortic arch calcification (AAC) can predict cardiovascular mortality. We conducted a prospective study to investigate factors associated with AAC in hemodialysis patients and examined its prognostic value in long-term outcome. METHODS A total of 712 hemod...

Glucocorticoid receptor (GR) is a ligand-activated nuclear receptor which is widely distributed in the brain. Many types of neurons and glial cells are known to express GR, but the expression of GR in ependymal cells has yet to be identified. The present study therefore was undertaken to determine whether ependymal cells express GR and coactivators of GR, such as steroid receptor coactivator 1 ...

background: today with population growing, surface water is one of the most important water resources used for domestic and industrial consumptions. in order to purify the surface water, coagulants materials are used. the purpose of this study was to assess the possibility of using poly aluminum chloride (pacl) in water refinery number 1 in city of orumieh and investigating its health effects. ...

BACKGROUND AND PURPOSE The factors that predict favorable outcome after local intra-arterial thrombolysis (LIT) remain unknown. We aimed to clarify these factors in patients with middle cerebral artery occlusion treated by LIT. METHODS We performed LIT in 26 consecutive patients who had middle cerebral artery occlusion with a modified Rankin scale (mRS) score <or=2 before stroke onset. We ass...