Phosphatidic acid (PA) and phytosphingosine-1-phosphate (phyto-S1P) have both been identified as lipid messengers mediating plant response to abscisic acid (ABA). To determine the relationship of these messengers, we investigated the direct interaction of PA with Arabidopsis sphingosine kinases (SPHKs) that phosphorylate phytosphingosine to generate phyto-S1P. Two unique SPHK cDNAs were cloned ...

were 7 associated procedures: 4 VSD closure, 2 balloon dilatation of aortic recoarctation and one main PA stenting. For PA band dilatation, 17 high pressure balloons were used and 11 low pressure balloons (mean balloon diameter: 12mm). Median RV/Ao pressure ratio dropped from 1 (± 0,3; 0,42-2,2) to 0,6 (± 0,3; 0,31,2) and median RV to PA gradient dropped from 61 mmHg (± 31; 42-160) to 19 mmHg (...

Our previous report showed that polyacetylene compound, 1-Heptadecene-11, 13-diyne-8, 9, 10-triol (PA) from the root of Cirsium japonicum var. ussuriense has anti-inflammatory activity. In this study we investigated the role of the PA as inhibitor of caspase-1, which converts prointerleukin-1β (proIL-1β) to active IL-1β and is activated by inflammasome involved in the inflammatory process. We t...

BACKGROUND Overexpression of tissue plasminogen activator (t-PA) in pancreatic cancer cells promotes invasion and proliferation in vitro and tumour growth and angiogenesis in vivo. AIMS To understand the mechanisms by which t-PA favours cancer progression, we analysed the surface membrane proteins responsible for binding specifically t-PA and studied the contribution of this interaction to th...

The kinetics of inhibition of tissue-type plasminogen activator (t-PA) by the fast-acting plasminogen activator inhibitor-1 (PAI-1) was investigated in homogeneous (plasma) and heterogeneous (solid-phase fibrin) systems by using radioisotopic and spectrophotometric analysis. It is demonstrated that fibrin-bound t-PA is protected from inhibition by PAI-1, whereas t-PA in soluble phase is rapidly...

Generation of the broad spectrum protease plasmin is facilitated by the tissue (t-PA) and urokinase (u-PA) plasminogen activators, within multiple physiological and disease states. Finely tuned control of this proteolytic cascade is exerted by the plasminogen activator inhibitors type-1 (PAI-1/SERPINE1) and 2 (PAI-2/SERPINB2). Expression of this network of activators and inhibitors by cells of ...

Interim Reports on work of the International Institute for Applied Systems Analysis receive only limited review. Views or opinions expressed herein do not necessarily represent those of the Institute, its National Member Organizations, or other organizations supporting the work. Abstract This paper develops a quantitative simulation model linking population parameters and education to land degr...

Author Affiliations: 1 Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 2 Biostatistics Facility, University of Pittsburgh Cancer Institute, Pittsburgh, PA 3 Department of Surgery, University of Pittsburgh, Pittsburgh, PA 4 Department of Pathology, University of Pittsburgh, Pittsburgh, PA 5 Department of Immunology, University of Pittsburgh, Pittsburgh, PA 6 Cancer Immunol...