The classical Weyl groups appear as special cases: for r = s = 1 we have the symmetric group G1,1,n = Sn, for r = 2s = 2 we have the hyperoctahedral group G2,1,n = Bn, and for r = s = 2 we have the group of even-signed permutations G2,2,n = Dn. We say that a permutation π ∈ Gr,s,n is an involution if π 2 = 1. More generally, we define G r,s,n = {σ ∈ Gr,s,n|σ m = 1}. Recently, Bagno, Garber and ...

The efficacy and safety of intermittent hypoxia training (IHT) were investigated in healthy, 60- to 74-yr-old men. Fourteen men (Gr 1) who routinely exercised daily for 20 to 30 min were compared with 21 (Gr 2) who avoided exercise. Their submaximal work-load power values before the IHT training were 94 +/- 3.7 and 66 +/- 3.1, respectively. Before and after 10 days of IHT, the ventilatory respo...

We have previously shown that the glucocorticoid receptor (GR) is required for skin homeostasis and epidermal barrier competence. To understand the transcriptional program by which GR regulates skin development, we performed a microarray analysis using the skin of GR(-/-) and GR(+/+) mice of embryonic d 18.5 and identified 442 differentially expressed genes. Functional clustering demonstrated o...

Intuitively, a pseudorandom generator (PRG) is a procedure that generates a pseudorandom distribution. A PRG shares the parameters of the underlying pseudorandom distribution: the class A of algorithms to which the generated distribution looks random, and a bound on how different the pseudorandom distribution can look from the uniform one for algorithms from A. Definition 1 (Pseudorandom genera...

BACKGROUND/AIM Infection with hepatitis C virus (HCV) frequently results in a persistent infection, suggesting that it has evolved efficient mechanism(s) for blocking the host cell's innate antiviral response. The immune response to virus infection results in activation or direct induction of the interferon regulatory factors (IRFs), which are a family of proteins involved in the regulation of ...

The vpr gene of human immunodeficiency virus type 1 (HIV-1) encodes a 15-kDa virion-associated protein that functions as a regulator of cellular processes linked to the HIV life cycle. We report the interaction of a 41-kDa cytosolic viral protein R interacting protein 1 (Rip-1) with Vpr in vitro. Rip-1 displays a wide tissue distribution, including relevant targets of HIV infection. Vpr protein...

We have previously proposed a novel mechanism for the coupled regulation of glucocorticoid receptor (GR) and c-jun transcription in triamcinolone acetonide (TA)-treated AtT-20 cells. This involved transcriptional interference of AP-1 (Fos/Jun)-driven gene transcription by the formation of inactive GR/Jun heterodimers. To further elucidate the molecular mechanism for GR autoregulation, the expre...