Molecular basis for LLT1 recognition by human CD161 (NKRP1A/KLRB1) Jun Kamishikiryo, Hideo Fukuhara, Yuki Okabe, Kimiko Kuroki and Katsumi Maenaka* From the Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan. Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Sanzou, Gakuen-cho, Fukuy...

It has been a long-lasting controversial issue as to whether or not the male genital organs, such as the testis and prostate, contain metallothioneins (MTs), a group of cysteine-rich heavy-metal-binding proteins that play a role in detoxifying heavy metals such as cadmium (Cd). Earlier studies reported that the rodent testis lacks MTs and concluded that this is why the testis is very susceptibl...

abstract nowadays, environmental pollution by heavy metals is one of the most serious threats of the world which needs effective remediation actions. the aim of this study was to investigate the potential use of atriplex [atriplex verucifera], salicornia [salicornia europaea] and chenopodium album in simultaneous uptake and accumulation of na and cd or pb in two calcareous soils with different ...

Intestinal fibrosis is the main pathological process in Crohn's disease (CD); acupuncture and moxibustion can inhibit the process of fibrosis in CD rats, but the regulatory mechanism remains unknown. The present study observed the effect of moxibustion on the extracellular signal-regulated kinase (ERK) signaling pathway in the CD rat. The result shows that the phosphorylation of the Ras, Raf-1,...

In the title compound, [Cd(C(3)H(3)N(4)O(2))(2)](n), the Cd(II) ion, located on a twofold rotation axis, is six-coordinated by two N atoms [Cd-N = 2.368 (2) Å] and four O atoms [Cd-O = 2.300 (1) and 2.260 (1) Å] from six 2-(1H-tetra-zol-1-yl)acetate (L) ligands in a distorted octa-hedral geometry. The metal centres are connected via the tridentate L ligands into a three-dimensional polymeric st...

The chemokine domain of fractalkine (FKN-CD) binds to the classical RGD-binding site of αvβ3 and that the resulting ternary complex formation (integrin-FKN-CX3CR1) is critical for CX3CR1 signaling and FKN-induced integrin activation. However, only certain cell types express CX3CR1. Here we studied if FKN-CD can activate integrins in the absence of CX3CR1. We describe that WT FKN-CD activated re...

A series of inorganic―organic hybrid compounds were analyzed by using X-ray crystallographic techniques to study the secondary interactions in cadmium bromide based hybrid materials. The phenomenon of metallophilic interactions with minimum Cd...Cd distance [3.962(1), 3.389(3) and 3.924(1) Å] has been observed in Cd2, Cd7 and Cd11 compounds whereas the metallophilicity is missing in other compo...

Transport of calcium (Ca) and cadmium (Cd) was examined along the gastro-intestinal tract (GIT) of freshwater and seawater Oncorhynchus mykiss irideus (FWT and SWTies respectively) using in vitro and in vivo experiments. Based on known physiological differences between FWT and SWT which aid in regulating ion levels and osmolarity, we hypothesized that SWT would have lower rates of Ca uptake. Al...

Thermodynamic study on the interaction of β-CD with poly ethylene oxide and poly acrylic acid was performed by isothermal titration calorimetry at 298K. when β-CD is added to the interpolymer complex, competition is created between host-guest and Hydrogen bond. Enthalpy of interaction between the β-CD and interpolymer complex was calculated using the extended solvation theory. P=1 Shows that w...

Cadmium (Cd) is a nonessential heavy metal that is highly toxic to living cells at very low concentrations. Most of the Cd in plants derives from soils. Owing to the large amounts consumed, cereals are the major source of dietary Cd, and Cd content in oat can exceed accepted limits. Plants have a set of mechanisms that control the uptake, accumulation, trafficking, and detoxification of Cd and ...