BACKGROUND Tumescent lidocaine anesthesia consists of subcutaneous injection of relatively large volumes (up to 4 L or more) of dilute lidocaine (≤1 g/L) and epinephrine (≤1 mg/L). Although tumescent lidocaine anesthesia is used for an increasing variety of surgical procedures, the maximum safe dosage is unknown. Our primary aim in this study was to measure serum lidocaine concentrations after ...

The objective of the present study was to evaluate acute oral toxicity, subchronic toxicity, and mutagenic potential of low molecular weight galactomannans based standardized fenugreek seeds extract (LMWGAL-TF) in laboratory animals rats as per Organization for Economic Co-operation and Development (OECD) guidelines. For the acute toxicity (AOT) study, LMWGAL-TF was orally administered to Sprag...

Objective: To investigate Acute, Sub-acute dermal toxicity, Mucus membrane irritation activity of Anuradha Oil’s (AO and AO11) – An herbal formulation having wound healing potential. Methods: The formulations were derived from Curcuma longa Linn and Glycyrrhiza glabra Linn rhizhomes, Hamiltonia suaveolens Roxb bark, Typha angustifolia Linn flowers, Azadirachta indica A. Juss leaves without/with...

The leaf base of Sorghum bicolor (Family: Gramineae, Poaceae) was cold-macerated with 70% v/v methanol. The aqueous methanolic extract was further fractionated into non-polar, medium polar and very polar components using hexane, ethylacetate and water (aqueous), respectively. The gastrointestinal effects of these extracts were tested on intestinal motility (transit) in mice, castor oilinduced d...

The objective of this study was to evaluate the potential toxicity methanolic extracts Pinus roxburghii branch (P. roxburghii) and Nauplius graveolens (N. graveolens). Single oral dosage administered male mice at increasing concentrations 100, 250,500,1000 2000 mg/kg body weight assess median LD50, which causes death 50% (one half) mice. Blood samples were collected end 14 day toxicological tri...