. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 108 The phylogenetic position of Porifera wi...

collagen molecule, the most abundant protein in the fibrotic matrix. Describing the synthesis of the interstitial collagens, Types I and III, de Crombrugghe et al. outline the complex series of translocation and splicing events that ultimately lead to the transcription of the chick a2(I), oal(I) and al(III) collagen genes. Kivirikko and Majamaa explore the regulation of post-translational modif...

Pin1 is a peptidyl prolyl cis-trans isomerase that only binds to and isomerizes phosphorylated serine/threonine-proline motifs, inducing conformational changes that alter target protein function and phosphorylation. We have shown previously that deficiency of another peptidyl prolyl isomerase, FK506 binding protein 12/12.6, alters endothelial NO synthase phosphorylation and causes endothelial d...