Factor analysis of psychotic symptoms frequently results in positive, negative, and disorganized dimensions, but heritability estimates have not yet been reported. Symptom dimensions are usually only measured in individuals with psychotic disorders. Here, it is valuable to assess influences acting via liability to psychosis and independent modifying effects. We estimated heritability for psycho...

To the Editor: Viguier et al. (1) reported that the ERCC1 codon 118 polymorphism has a predictive value in colorectal cancer patients treated with platinum combination chemotherapy. However, there are contradictory reports on the effects of this polymorphism on the survival of cancer patients. Although Viguier et al. suggested that cancer patients carrying a variant genotype survived for a long...

Large-conductance voltage- and Ca(2+)-activated K(+) (BK) channels are critical regulators of detrusor smooth muscle (DSM) excitability and contractility. PKC modulates the contraction of DSM and BK channel activity in non-DSM cells; however, the cellular mechanism regulating the PKC-BK channel interaction in DSM remains unknown. We provide a novel mechanistic insight into BK channel regulation...