A number of human malignancies exhibit sustained stimulation, mutation, or gene amplification of the receptor tyrosine kinase human mesenchymal-epithelial transition factor (c-Met). ARQ 197 is a clinically advanced, selective, orally bioavailable, and well tolerated c-Met inhibitor, currently in Phase 3 clinical testing in non-small cell lung cancer patients. Herein, we describe the molecular a...

Abstract Aim Accurate and comprehensive operation notes are crucial for patient safety, quality assurance medico-legal purposes. Inguinal hernia repair is one of the most common surgical procedures. Thus, operative documentation should be precise standardised. The GROIN project aims to improve inguinal using an evidence-based proforma note composition software. Methods We retrospectively review...

R. Siddheswaran*, R.V. Mangalaraja*, Ricardo E. Avila, Maria Elena Gómez, D.Manikandan, Marta Lopez, C. Esther Jeyanthi and S. Ananthakumar Advanced Ceramics and Nanotechnology Laboratory, Department of Materials Engineering, University of Concepcion, Concepcion, Chile Personal Dosimetry Section, Chilean Commission of Nuclear Energy, Santiago, Chile Department of Physics, University of Valle, C...

1 Prasanta K. Panigrahi, Indian Institute of Science Education and Research (Kolkata), Salt Lake City, Kolkata 700 106, India and Physical Research Laboratory, Navrangpura, Ahmedabad 380 009, India. ‖∗∗ 2 Sayantan Ghosh, The Insitute of Mathematical Sciences, C.I.T. Campus, Taramani, Chennai 600 113, India.†† 3 P. Manimaran, Center for Mathematical Sciences, C R Rao Advanced Institute of Mathem...

Background: Female infertility varies widely by geographic location around the world. In 2010, there was an estimated 48.5 million infertile couples worldwide, and from 1990 to 2010 there was slight change in levels of infertility in most of the world. In 2010, the countries with the lowest rates of female infertility included the South American countries of Peru, Bolivia, Ecuador and Bolivia, ...