RAW 264.7 murine macrophages were exposed to the pyrrole-based compound 3,5-Dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester (JG-03-14), which is a known microtubule depolymerizing agent with antitumor activity [1,2,3]. In this study exposure to JG-03-14 reduced the production of pro-inflammatory molecules by macrophages activated with lipopolysaccharide (LPS). Treatment...

Es t ima te s of increases in future agricultural production in response to increases in carbon dioxide (C02) concentrations in the atmosphere are often based on the beneficial physiological effect of C02 enrichment on plant growth, especially in Ca plants. However, these estimates fail to consider the negative impact of ozone (03) air pollution on crop production. Increases in tropospheric con...

The mechanism of action for a new lead stilbene compound coded SK-03-92 with bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA) is unknown. To gain insight into the killing process, transcriptional profiling was performed on SK-03-92 treated vs. untreated S. aureus. Fourteen genes were upregulated and 38 genes downregulated by SK-03-92 treatment. Genes involved in ...

Address correspondence to: Alan M. Preston, PhD, Biochemistry Department, University of Puerto Rico Medical Sciences Campus, PO Box 5067, San Juan, Puerto Rico 00936-5067. Email: [email protected] Objective: Knowledge of the diet of specific populations is of importance in the assessment of nutrient intake. Herein, we assess the reproducibility and validity of an interviewer-administered foo...