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Background and aims—Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology. Abnormalities in immune regulation and genetic associations suggest that PSC is an immune mediated disease. Several polymorphisms within the tumour necrosis factor á (TNF-á) and interleukin 10 (IL10) promoter genes have been described which influence expression of these cytokine...
BACKGROUND AND AIMS Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology. Abnormalities in immune regulation and genetic associations suggest that PSC is an immune mediated disease. Several polymorphisms within the tumour necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10) promoter genes have been described which influence expression of these...
©2004 British Editorial Society of Bone and Joint Surgery doi:10.1302/0301-620X.86B5. 15058 $2.00 J Bone Joint Surg [Br] 2004;86-B:631-5. The treatment for most patients with slipped capital femoral epiphysis (SCFE) is well established but controversy remains as to how to manage the more difficult cases. The advent of fixation by a single cannulated screw has made this the operation of choice. ...
©2003 British Editorial Society of Bone and Joint Surgery doi:10.1302/0301-620X.85B4.14215 $2.00 J Bone Joint Surg [Br] 2003;85-B:469-77. The current state of knowledge of Dupuytren’s disease is rather like a complex jigsaw puzzle, many pieces of which have been gathered in many countries, but exactly where each fits into the finished puzzle is not clear. Some may not even belong to this partic...
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