OBJECTIVE To examine the ability of vasodilator response to predict survival in a diverse cohort of patients with pulmonary hypertension (PH). PATIENTS & METHODS A total of 214 consecutive treatment-naive patients referred for invasive PH evaluation were enrolled between November 1998 and December 2008. Vasoreactivity was assessed during inhalation of 40 parts per million nitric oxide (iNO) a...

CONTEXT Even though the strong association between physical inactivity and ill health is well documented, 60% of the population is inadequately active or completely inactive. Traditional methods of prescribing exercise have not proven effective for increasing and maintaining a program of regular physical activity. OBJECTIVE To compare the 24-month intervention effects of a lifestyle physical ...

Induction therapy for multiple myeloma with bortezomib (Velcade), lenalidomide (Revlimid), and dexamethasone (d) (VRd) was traditionally administered as given twice weekly on a 3 week cycle. A modified schedule of has been adopted over time to decrease treatment burden patients reduce treatment-emergent neuropathy. This study evaluates the response rates outcomes different schedules in VRd firs...

A recently developed apparatus provides on-line continuous monitoring of systemic vascular resistance (SVR) by means of simple computer analysis of the peripheral arterial waveform. The fundamental equation of this method is Ri = P'/(dP/dt), where dP/dt is the peak dP/dt of the peripheral arterial waveform, P' is the pressure at time of peak dP/dt, and Ri is a resistance index that bears a dire...

BACKGROUND Although several reports address characteristic 12-lead electrocardiographic findings of outflow tract ventricular arrhythmias (OT-VAs), the accuracy of electrocardiogram-based algorithms to predict the OT-VA origin is sometimes limited. OBJECTIVE This study aimed to develop a magnetocardiography (MCG)-based algorithm using a novel adaptive spatial filter to differentiate between V...

Endothelin-1 (ET-1) is known to have potent contractile and proliferative effects on vascular smooth muscle cells and is known to induce myocardial cell hypertrophy. We studied the pathophysiological role of endogenous ET-1 in rats with monocrotaline-induced pulmonary hypertension. Four-week-old rats were given a single subcutaneous injection of 60 mg/kg monocrotaline (MCT rats) or saline (cont...

OBJECTIVE To evaluate portable methods for documenting ocular muscle limitation that might be used at multiple sites in a clinical trial. METHODS In a prospective consecutive case series, 2 examiners independently evaluated 3 methods of ocular muscle duction testing: a grading scale of 0 to -5 that is in clinical use, the Kestenbaum limbus test using a ruler to measure the millimeters of ocul...

This study intends to analyze the dimensions of channel, subdivision, and tapping infrastructure. The mainstay discharge was analyzed using Mock method, analysis irrigation water needs based on Irrigation Planning Standard KP-01, recalculation building for, existing planned in accordance with KP- 03. Rainfall data were algebraic average method. findings indicated that highest primary discharge,...

ovarian follicle response and corpus luteum formation following induction of ovulation using gonadotropin-releasing hormone (gnrh) analogues and luteinizing hormone (lh) in bactrian camel were characterized. bactrian camels with a mature follicle (13-19.6 mm) received: 1) natural porcine lh (25 mg, iv, n = 4), 2) buserelin (20 μg, iv, n = 4) and 3) alarelin (25 μg, im, n = 4). daily ultrasonogr...

PURPOSE To compare the use of the distal anterolateral accessory (DALA) portal with the anterolateral (AL) and midanterior (MA) portals during arthroscopic hip labral repair. METHODS Standard AL, MA, and DALA portals were created on 6 cadaveric hip specimens. Four 2.4-mm pins were placed in the acetabular rim to the depth of a standard anchor using a drill guide. Pins were placed in the 12 to...