Drug therapies grow more complex, thus a wide range of drug-related problems (DRPs) may arise. Adverse drug reactions (ADRs) are responsible for approximately 10% of all DRPs. The most severe form of ADR is an anaphylactic shock. It is estimated that severe anaphylaxis affects annually 1–3 per 10 000 people and causes death of 0.65–2% of those patients, i.e. 1–3 per 1 000 000 people. Fatal drug...

In this issue, Hill, AbouZahr &Wardlaw (1) present new estimates of maternal mortality for 1995. They have carefully adjusted the data for underreporting, and used statistical models in countries lacking relevant data. They have obtained a global estimate ranging from some 303 000 to 822 000 maternal deaths. This very large range is mostly the consequence of the limited quality of available dat...

Malaria with over 3 million deaths per year remains the foremost killer among all diseases and causes 400 000 cases of severe maternal anaemia and from 75 000-200 000 infant deaths annually in sub-Saharan Africa[1]. Malaria is more severe in pregnant women than nonpregnant women leading to altered placental pathology and fetal abnormalities[2]. The role of heat shock proteins (hsps) in infectio...

6.1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 000 6.2 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . 000 6.2.1 What is Global Change? . . . . . . . . . . . . . . . . . . . . . 000 6.2.2 Rationale for Considering Mycorrhiza in Global Change Biology . . . . . . . . . . . . . . . . . . . . 000 6.3 Global Change: Multiple Factors . . . . . . . . . . . . ....

I would like to begin my intervention by giving figures on the epidemiological situation relating to drug use in France. Until the first half of this year, thiknownAIDS cases among drug users was 4387 cases, i.e. 27.4% of all cases in France in 1992. The number of cases, and therefore the percentage, have been on the increase since 1984. It is estimated that 40-50% of all users are seropositive...

Sequences with ultrashort echo times enable new applications of MRI, including bone, tendon, ligament, and dental imaging. In this article, a sequence is presented that achieves the shortest possible encoding time for each k-space point, limited by pulse length, hardware switching times, and gradient performance of the scanner. In pointwise encoding time reduction with radial acquisition (PETRA...