BACKGROUND The aim of the present study was to examine if differences in the endocannabinoid (ECB) system might be linked to strain specific variations in reward-related behavior in Fischer344 (Fischer) and Wistar rats. METHODOLOGY/PRINCIPAL FINDINGS Two rat strains, the Fischer and the Wistar strain, were tested for different aspects of reward sensitivity for a palatable food reward (sweeten...

Ceramide levels are elevated in mantle cell lymphoma (MCL) cells following treatment with cannabinoids. Here, we investigated the pathways of ceramide accumulation in the MCL cell line Rec-1 using the stable endocannabinoid analogue R(+)-methanandamide (R-MA). We further interfered with the conversion of ceramide into sphingolipids that promote cell growth. Treatment with R-MA led to increased ...

Clinical and neurobiological findings suggest that the cannabinoids and the endocannabinoid system may be implicated in the pathophysiology and treatment of schizophrenia. We described that the spontaneously hypertensive rats (SHR) strain presents a schizophrenia behavioral phenotype that is specifically attenuated by antipsychotic drugs, and potentiated by proschizophrenia manipulations. Based...

Brief depolarization of cerebellar Purkinje cells was found to inhibit parallel fiber and climbing fiber EPSCs for tens of seconds. This depolarization-induced suppression of excitation (DSE) is accompanied by altered paired-pulse plasticity, suggesting a presynaptic locus. Fluorometric imaging revealed that postsynaptic depolarization also reduces presynaptic calcium influx. The inhibition of ...

The N-methyl-D-aspartate (NMDA) receptor has long been implicated in the pathophysiology of schizophrenia. NMDA receptor antagonists induce psychotic states in humans and when administered to rodents promote lasting behavioural phenotypes relevant to schizophrenia (Javitt and Zukin, 1991; Abi-Saab et al., 1998; Javitt, 2007). Further, schizophrenia brain tissue contains reduced expression and f...

This study aimed to explore the effect of aged pork fat on quality and volatile compounds Chi-aroma Baijiu during ageing stage. Result showed that glycerol total ester contents CBN, CB1, CB3 CB5 were significantly higher than in BL (P < 0.05), but acid did not change > 0.05). Moreover, there was a difference concentration OAVs among samples. With year increased, concentrations esters aldehydes ...

There is evidence of altered vascular function, including cerebrovascular, in Alzheimer's disease (AD) and transgenic models of the disease. Indeed vasoconstrictor responses are increased, while vasodilation is reduced in both conditions. β-Amyloid (Aβ) appears to be responsible, at least in part, of alterations in vascular function. Cannabinoids, neuroprotective and anti-inflammatory agents, i...