background & aim: st john's wort (hypericum perforatum l.) contains hypericin and hyperforin as the main components of the extract that binds with gaba and sigma opioid receptors. this herb has many pharmacological effects, including analgesic, sedative, soothing, antispasmodic, anticonvulsant, anti-depressant, and anti-bacteria. in this study examined the effect of two concentrations of hy...

A major mental disorder that affects young people, schizophrenia ( Greek “split mind”) is characterized by a variety of symptoms including but not limited to , loss of contact with reality, bizarre behaviour, disorganized thinking, speech, decreased emotional expressiveness ,loss of contact with reality and society and long-lasting, not completely successful treatment. Anti-psychotics are the d...

BACKGROUND An efficient method for the identification of medicinal plant products is now a priority as the global demand increases. This study aims to develop a DNA-based method for the identification and authentication of plant species that can be implemented in the industry to aid compliance with regulations, based upon the economically important Hypericum perforatum L. (St John's Wort or Gua...

Essential oil, ethanolic extract and decoction of 10 plant species from interior Portugal were analyzed for their activity towards acetylcholinesterase (AChE) enzyme and their antioxidant activity. Of these, Melissa officinalis, Paronychia argentea, Sanguisorba minor, Hypericum undulatum and Malva silvestris are used in herbal medicine, Laurus nobilis and Mentha suaveolens as condiments, and Sa...

One of the top-selling medicinal products worldwide is Hypericum perforatum (St. John's Wort). Despite its cosmopolitan distribution and utilization, little is known regarding the relationship of the bioactive compounds in H. perforatum to the plants from which they are purportedly derived. In this study, amplified fragment length polymorphism (AFLP) analysis of 56 Hypericum accessions, represe...

The primary goal of the present study aimed to evaluate the prophylactic effect of Hypericum Perforatum L. extract on memory dysfunction induced by scopolamine in adult male albino rats (Rattus norvegicus Berkenout). Rats administered daily P.O Hypericum Perforatum L. extract (350 mg/kg) for two, four, eight weeks and the group of rats at the end of each interval intraperitoneally administered ...

The widely-used Chinese medicinal herb Hypericum japonicum, also known as Hypericum japonicum Thunb or Tianjihuang, displays potent anti‑carcinogenic effects against liver cancer. However, the molecular mechanism underlying the therapeutic effects of Hypericum japonicum remains to be elucidated. The present study investigated the in vivo efficacy of ethyl acetate extract of Hypericum japonicum ...