RATIONALE Inhibition of glycogen synthase kinase-3 (GSK-3) protects the heart during ischemia/reperfusion (I/R), yet the underlying mechanisms of cardioprotection afforded by beta isoform-specific inhibition GSK-3 remain to be elucidated. OBJECTIVE We studied the molecular mechanism mediating the effect of GSK-3β activation/inhibition upon myocardial injury during prolonged ischemia and I/R. ...

PURPOSE Glycogen synthase kinase-3β (GSK-3β) is a serine/threonine kinase involved in cancer development. Herein, we demonstrated the role of GSK-3β in endometrial cancer (EC) and identified new therapeutic targets. RESULTS GSK-3β was overexpressed in EC tissues, and was positively correlated with International Federation of Gynecology and Obstetrics (FIGO) staging, dedifferentiation, and myo...

BACKGROUND Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer (BC) prevention. It may also be related to prognosis after diagnosis and treatment. The aim of our study was to determine the prevalence of vitamin D deficiency as measured by serum 25-hydroxy vitamin D (25-OHD) levels in patients with BC and to evaluate its correlations with life-styl...

AIMS To determine whether quantitative differences in sector based slope can differentiate between eyes with ocular hypertension with and without glaucomatous disc changes and eyes with normal tension glaucoma with glaucomatous disc changes. METHODS Seventy six eyes with ocular hypertension or early glaucomatous disc changes were consecutively categorised into three groups: 22 eyes with ocula...

OBJECTIVE To assess the influence of immobilization upon vitamin D status and bone mass in chronically hospitalized, disabled, elderly patients following stroke. DESIGN cross-sectional study. SETTING Department of geriatric neurology in a Japanese hospital. SUBJECTS 129 chronically hospitalized, disabled, elderly stroke patients and 28 age-matched controls. RESULTS We observed a deficie...

OBJECTIVE To assess the effect of 25-hydroxyvitamin D (25-OHD) levels on pregnancy outcomes and birth variables. DESIGN Systematic review and meta-analysis. DATA SOURCES Medline (1966 to August 2012), PubMed (2008 to August 2012), Embase (1980 to August 2012), CINAHL (1981 to August 2012), the Cochrane database of systematic reviews, and the Cochrane database of registered clinical trials. ...

background : there is no data available regarding vitamin d status among patients with hip fractures in iran. this study aimed to determine whether postmenopausal women with low trauma hip fractures have lower vitamin d levels comparing to the control group.   materials and methods: vitamin d (25-ohd) level and the prevalence of hypovitaminosis d among 73 postmenopausal women with fracture of t...

BACKGROUND Hypovitaminosis D is unrecognized and remarkably common in geriatric patients, with various clinical manifestations. The purpose of this study was to prospectively assess the vitamin D (VD) status in newly admitted psychogeriatric patients, and to study the correlation of VD status with indicators of calcium metabolism. METHODS A valid VD sample, as measured by serum 25-hydroxyvita...

AIM To determine the prevalence of vitamin D hypovitaminosis among obese and overweight schoolchildren. DESIGN A cross-sectional population based sample. METHODS In a cross-sectional study, 301 students (177 girls and 124 boys) aged 11-19 years were selected by multistage stratified sampling design. Subjects were classified according to their body mass index as obese, overweight and normal....

PURPOSE We investigated the vitamin D status of preterm infants to determine the incidence of vitamin D deficiency. METHODS A total of 278 preterm infants delivered at Kyungpook National University Hospital between January 2013 and May 2015 were enrolled. The serum concentrations of calcium, phosphorous, alkaline phosphatase, and 25-hydroxyvitamin D (25-OHD) were measured at birth. We collect...