Viral protein R (Vpr), an apoptogenic accessory protein encoded by HIV-1, induces mitochondrial membrane permeabilization (MMP) via a specific interaction with the permeability transition pore complex, which comprises the voltage-dependent anion channel (VDAC) in the outer membrane (OM) and the adenine nucleotide translocator (ANT) in the inner membrane. Here, we demonstrate that a synthetic Vp...

Abstract Visual place recognition (VPR) is the process of recognising a previously visited using visual information, often under varying appearance conditions and viewpoint changes with computational constraints. VPR related to concepts localisation, loop closure, image retrieval critical component many autonomous navigation systems ranging from vehicles drones computer vision systems. While co...

Pre-mRNA splicing is a critical step in gene expression for metazoans. Several viral proteins regulate the splicing of pre-mRNAs through complex interactions with the host cell RNA splicing machinery. Here, we focus on a novel function of HIV-1 Vpr, which selectively inhibits cellular and viral pre-mRNA splicing via interactions with components of the spliceosome complex. This review discusses ...

UNLABELLED There has been extraordinary progress in understanding the roles of lentiviral accessory proteins in antagonizing host antiviral defense proteins. However, the precise primary function of the accessory gene Vpr remains elusive. Here we suggest that engagement with the DNA damage response is an important function of primate lentiviral Vpr proteins because of its conserved function amo...

We describe the capabilities of and algorithms used in a new FPGA CAD tool, Versatile Place and Route (VPR). In terms of minimizing routing area, VPR outperforms all published FPGA place and route tools to which we can compare. Although the algorithms used are based on previously known approaches, we present several enhancements that improve run-time and quality. We present placement and routin...

We describe the capabilities of and algorithms used in a new FPGA CAD tool, Versatile Place and Route (VPR). In terms of minimizing routing area, VPR outperforms all published FPGA place and route tools to which we can compare. Although the algorithms used are based on previously known approaches, we present several enhancements that improve run-time and quality. We present placement and routin...

INTRODUCTION Viral protein R (Vpr) of human immunodeficiency virus type 1 (HIV-1) has been described as being involved in the progression of AIDS, and specific mutations are associated with long-term non-progressor patients. CASE PRESENTATION We describe the case of a child with repeated ear infections who was otherwise healthy. The patient, a 5-year-old boy, was HIV-1 positive and the viral ...

The T-Vpack and VPR toolset [6, 7] have been widely used to perform FPGA CAD and architecture research, but have not evolved over the past decade to include many architectural features now present in modern FPGAs. This paper describes a new version of the toolset that includes four significant features: The router now supports a broad range of single-driver routing architectures [29, 4, 16] whi...

We describe the capabilities of and algorithms used in a new FPGA CAD tool, Versatile Place and Route (VPR). In terms of minimizing routing area, VPR outperforms all published FPGA place and route tools to which we can compare. Although the algorithms used are based on previously known approaches, we present several enhancements that improve run-time and quality. We present placement and routin...

The bacterial defense system CRISPR (clustered regularly interspaced short palindromic repeats) has been explored as a powerful tool to edit genomic elements. In this study, we test the potential of CRISPR Csy4 RNA endoribonuclease for targeting HIV-1. We fused human codon-optimized Csy4 endoribonuclease with VPR, a HIV-1 viral preintegration complex protein. An HIV-1 cell model was modified to...