Vascular endothelial-cadherin (VE-cadherin) is exclusively expressed in endothelial cells and is strictly located at cell-to-cell junctions. As the other members of the cadherin family, VE-cadherin is able to mediate a homotypic type of cellular interaction in a Ca2+-dependent manner. In the mouse embryo, VE-cadherin transcripts are detected at the earliest stages of vascular development. To as...

Vascular endothelial (VE)-cadherin is a cell-cell adhesion molecule involved in endothelial barrier functions. Previously, we reported that cAMP-Epac-Rap1 signal enhances VE-cadherin-dependent cell adhesion. Here, we further scrutinized how cAMP-Epac-Rap1 pathway promotes stabilization of VE-cadherin at the cell-cell contacts. Forskolin induced circumferential actin bundling and accumulation of...

Vascular endothelium (VE), the monolayer of endothelial cells that lines the vascular tree, undergoes damage at the basis of some vascular diseases. Its integrity is maintained by VE-cadherin, an adhesive receptor localized at cell-cell junctions. Here, we show that VE-cadherin is also located at the tip and along filopodia in sparse or subconfluent endothelial cells. We observed that VE-cadher...

Two experiments were conducted to determine the effects of vitamin E (VE) and Arginine (ARG) on humoral and cellular immunity of broiler chickens, with 2 levels of ARG: normal (NARG, 1.2% in the feed) and high ARG (HARG, additional 0.3% ARG in the drinking water); and 3 levels of VE (40, 80, and 400 IU / kg feed). A cornsoybean meal diet and water were provided ad libitum throughout the study. ...

Amaç: Bu çalışmada hemodiyaliz ve sürekli ayaktan periton diyalizi (SAPD) tedavisi uygulanan kronik böbrek hastaları ve kontrol grubu katılımcılarını depresyon, anksiyete bozuklukları, yaşam kaliteleri ve stresle başa çıkma tutumları açısından karşılaştırmak, psikiyatrik hastalıklarla karşılaşma sıklığını ve bununla ilişkili faktörleri belirlemek amaçlanmıştır. Yöntem: Çalışmamıza 42 hemodiyali...

The objective of this study was to evaluate the effect of dietary functional ingredients vitamin E (VE), Se, and conjugated linoleic acid (CLA), alone or in combination, on the quality of irradiated turkey breast meat. A total of 480 male turkeys (11-wk-old, raised on a cornsoybean basal diet) were randomly allotted to 32 pens and fed 1 of 8 experimental diets (4 pens/treatment) supplemented wi...

The mechanisms by which catenins regulate cadherin function are not fully understood, and the precise function of p120 catenin (p120ctn) has remained particularly elusive. In microvascular endothelial cells, p120ctn colocalized extensively with cell surface VE-cadherin, but failed to colocalize with VE-cadherin that had entered intracellular degradative compartments. To test the possibility tha...

Özet Amaç: Tek başına veya birlikte sistemik olarak verilen tramadol ve gabapentinin farelerde akut ağrıda olası antinosiseptif etklerini araştırmaktır. Gereç ve Yöntem: Hayvan etik komitesinin onayı sonrası; 96 BALB/c albino dişi fare 12 gruba ayrıldı: (I) Enjeksiyon yapılmaksızın kontrol grubu, (II) salin uygulanan kontrol grubu, (III)-(IV) tramadol 10 mg/kg veya 30 mg/kg uygulanan gruplar, (...

AIM To investigate the effect of formaldehyde (FA) on testes and the protective effect of vitamin E (VE) against oxidative damage by FA in the testes of adult rats. METHODS Thirty rats were randomly divided into three groups: (1) control; (2) FA treatment group (FAt); and (3) FAt + VE group. FAt and FAt + VE groups were exposed to FA by inhalation at a concentration of 10 mg/m(3) for 2 weeks....

Kurumlar taraf ndan bar nd r lan veri ve bu verilere eri3im s kl § gittikçe artmaktad r. Artan veri boyutuyla analiz i3lemleri de karma3 k hale gelmektedir. Günümüzde birden çok veri taban ayn amaca yönelik i3lemlerde beraber kullan labilmektedir. Veri tabanlar n n ortak kullan mlar nda ba§lant problemleri, hangi tablonun hangi veri taban ndan geldi§inin bilinememesi, i3leme (commit) ve geri al...