Acquired chemoresistance has curtailed cancer survival since the dawn of chemotherapy. Accumulating evidence suggests a major role for cancer stem cells (CSC) in chemoresistance, although their involvement in acquired resistance is still unknown. The use of aspirin has been associated with reduced cancer risk and recurrence, suggesting that the anti-inflammatory drug may exert effects on CSCs. ...

Radiotherapy is commonly used for cancer treatment. However, it often results in side effects due to radiation damage in normal tissue, such as bone marrow (BM) failure. Adult hematopoietic stem and progenitor cells (HSPC) reside in BM next to the endosteal bone surface, which is lined primarily by hematopoietic niche osteoblastic cells. Osteoblasts are relatively more radiation-resistant than ...

Tumor-induced bone disease is a major cause of morbidity and mortality. Many cancers either grow predominantly in bone, such as multiple myeloma, or metastasize to bone, such as breast and prostate cancer. Irrespective of the organ of origin tumor cells induce significant changes in bone compromising skeletal integrity and resulting in bone pain, hypercalcemia and an increased likelihood of fra...

Parkinson's disease has been associated with the selective loss of neurons in the substantia nigra pars compacta. Increasing evidence suggests that oxidative stress plays a major role. The resulting increase in reactive oxygen species triggers a sequence of events that leads to cell damage, activation of microglia cells and neuroinflammatory responses. Our objective was to study whether chronic...

BACKGROUND Possible mechanisms of Alzheimer Disease (AD) such as inflammation and oxidative stresses in the brain led us to investigate potential AD therapeutics of Melilotus officinalis, an herbal extract, with possible role as an anti-inflammatory and anti-oxidant agent. Among different genes which had important role in Sporadic AD (SAD), three genes including DAXX, NFkB and VEGF have shown s...

Microarray studies generating lists of genes with altered expression in placentas from pregnancies complicated with pre-eclampsia (PE) have so far been published in several different studies. Working under the assumption that altered gene expression in PE may be the result of altered expression of regulatory transcription factors (TFs), we looked for over-represented TF-binding sites (TFBSs)-wh...

Epithelial sodium channels (ENaCs) controls vectorial Na across epithelia thus playing a central role in all aspects of fluid clearance in the body. The aim of this study was to investigate in vitro time dependant model of hypoxia induced reduction in vectorial Na and fluid transport across the alveolar epithelium. AEC exposed to 3% O2, for different time periods (1 h, 3h, 6h, 12h, 24h and 48 h...