This note discusses two integral variants of the input-to-state stability (ISS) property, which represent nonlinear generalizations of L stability, in much the same way that ISS generalizes L∞ stability. Both variants are equivalent to ISS for linear systems. For general nonlinear systems, it is shown that one of the new properties is strictly weaker than ISS, while the other one is equivalent ...

Major trauma is commonly defined using an Injury Severity Score (ISS) threshold of 15. Since this threshold was formulated, there have been significant developments in both the Abbreviated Injury Scale underlying the ISS, and trauma management techniques, both in the preventive and acute-care phases of trauma management. This study assesses whether this ISS threshold is appropriate when evaluat...

In this paper, a novel technique of parametrization of supply rates is developed for establishing Input-to-State Stability(ISS) and dissipative properties of nonlinear interconnected systems. In the application of the ISS small-gain theorem, selecting supply rates to establish stability properties is not a straightforward task. This paper proposes useful tools for selecting supply rates by allo...

Activation of CD40 by CD154 induces antigen-presenting cells (APC) to express immune costimulatory molecules, thereby enhancing their APC activity. Oligonucleotides (ODN), containing immunostimulatory DNA sequences (ISS) with nonmethylated CpG dinucleotides in a defined motif, also can induce similar changes in APC. In this study, we examined whether infection with recombinant adenovirus (Ad) e...

As the duration of spaceflight increases, the impact of habitability on mission success becomes significant. Habitability is based on the qualities and capabilities of an environment that enable people to work and live. Poor habitability can impact productivity, safety, well-being, and performance. The International Space Station (ISS) Operational Habitability Project has been established to ad...

AIMS Lead fractures in implantable cardioverter-defibrillator (ICD) patients may cause inappropriate shocks (ISs). An early diagnosis is essential to prevent adverse clinical events. Implantable cardioverter-defibrillator remote monitoring (RM) permits prompt detection of lead fracture. Limited data define the impact of RM on ISs specifically related to lead fracture. We sought to compare the n...

Humans have two nearly identical copies of the Survival Motor Neuron (SMN) gene, SMN1 and SMN2. In spinal muscular atrophy (SMA), SMN2 is not able to compensate for the loss of SMN1 due to exclusion of exon 7. Here we describe a novel inhibitory element located immediately downstream of the 5' splice site in intron 7. We call this element intronic splicing silencer N1 (ISS-N1). Deletion of ISS-...

This paper investigates the developmental process through which L2 learners acquire two „imperfective‟ aspect markers in Korean, -ko iss(progressive and resultative) and -a iss(resultative) which attempts to identify language-general and language-specific patterns in the L2 acquisition of the Korean imperfective aspect by Japanese learners by comparing the results with previous research. Study ...

There is significant heterogeneity in the clinicopathological characteristics of intermediate hepatocellular carcinoma (IHCC). This also translates to treatment as transarterial chemoembolization (TACE) is used as first-line therapy for patients with IHCC; however, in Asia liver resection (LR) is preferred. Prognostic tools are required to help guide clinicians in deciding treatment options. Th...

Six kinds of new insertion sequences (ISs), IS667 to IS672, a group II intron (Oi.Int), and an incomplete transposon (Tn852loi) were identified in the 3,630,528-bp genome of the extremely halotolerant and alkaliphilic Oceanobacillus iheyensis HTE831. Of 19 ISs identified in the HTE831 genome, 7 were truncated, indicating the occurrence of internal rearrangement of the genome. All ISs except IS6...