background: iron chelators are an important part of management of patients with thalassemia. it is prudent to compare efficacy of different iron chelators in treatment of iron overload in these patients who receive regular blood transfusion. we aimed to compare the efficacy and safety of available oral iron chelator; deferasirox (exjade®) with deferasirox (osveral®) in reducing iron overload in...

in this study the iron status of pregnant women in two different socio-economic groups and also the effect of multigravidity on iron status of the mothers were investigated. blood samples were with drawn from 165 mothers (91 from farah and 74 from missaghieh maternity hospital) immediately after delivery and hemoglobin, hematocrit, serum iron, total iron-binding capacity (tibc) and total protei...

Iron deficiency is prevalent in children and infants worldwide. Zinc deficiency may be prevalent, but data are lacking. Both iron and zinc deficiency negatively affect growth and psychomotor development. Combined iron and zinc supplementation might be beneficial, but the potential interactions need to be verified. In a randomized, placebo-controlled trial using 2 x 2 factorial design, 609 Thai ...

OBJECTIVE : To determine the impact of contaminant iron and geophagy on iron intake and status of persons living in developing countries. DESIGN : Literature for review was identified by searching Medline and Agricola, from appropriate other texts and from three reports from the Opportunities for Micronutrient Interventions (OMNI) Project of USAID. SETTING : The dietary intake of iron by pe...

Standard parenteral iron preparations such as ferric sucrose and ferric gluconate are considered to be degraded in the reticuloendothelial cells. The iron is subsequently incorporated into transferrin. It was also reported that these iron preparations donate iron directly to plasma transferrin. Hepatocytes seemed unaffected. We show that this picture is incorrect. To obtain quantitative data, i...

The iron stores of 32 healthy pregnant women were evaluated longitudinally during pregnancy and 6 months post partum by serum ferritin assay and by bone marrow iron content. Half of the women were receiving oral iron while the others were not given iron supplementation. Women receiving iron could maintain their iron stores throughout the pregnancy. By contrast, women without iron therapy had lo...

background: the world health organization estimates that 58% of pregnant women in developing countries are anemic. in spite of the fact that most ministries of health in developing countries have policies to provide pregnant women with iron supplementation, prevalence of maternal anemia has not declined significantly. the aim of this study was to assess adherence to the current recommendation i...

background oxidative stress plays a major pathogenic role in liver injury following chronic hepatitis b. glutathione peroxidase (gpx) has a central role in regulating the oxidative state. hepatitis b virus (hbv) results in down-regulation of gpx. on the other hand, iron homeostasis is disrupted in hbv infected patients. therefore, the objective of this study was to assess the interplay of gpx a...

Nano-fertilizers can increase value of products in agriculture. Iron plays many important and essential roles in plant growth and development as compared to other micronutrients. In the present study, effects of different levels of enriched nano chelated Iron fertilizer (25, 50, 100, and 200 mg l-1)  were investigated in comparison with the common Iron (FeSO4.7H2O) on in vitro proliferation of ...

Oxidation of sulfide-containing ores is the main cause of Acid Mine Drainage (AMD), which is an environmental problem associated with both the abandoned and active mines. Iron-bearing sulfide minerals can be oxidized and form mine waters with high sulfate content, low pH, high electrical conductivity, high redox potential, and high concentrations of iron, aluminum, and other heavy metals. In th...