نتایج جستجو برای: ژن hdac4

تعداد نتایج: 16335  

2015
Da Liu Donglu Wu Linhong Zhao Yang Yang Jian Ding Liguo Dong Lianghai Hu Fei Wang Xiaoming Zhao Yong Cai Jingji Jin Tim Thomas

Histone post-translational modification heritably regulates gene expression involved in most cellular biological processes. Experimental studies suggest that alteration of histone modifications affects gene expression by changing chromatin structure, causing various cellular responses to environmental influences. Arsenic (As), a naturally occurring element and environmental pollutant, is an est...

2013
Min He Bin Zhang Xinbing Wei Ziying Wang Baoxia Fan Pengchao Du Yan Zhang Wencheng Jian Lin Chen Linlin Wang Hao Fang Xiang Li Ping-An Wang Fan Yi

Histone deacetylases (HDACs)-mediated epigenetic mechanisms play critical roles in the homeostasis of histone acetylation and gene transcription. HDAC inhibitors have displayed neuroprotective properties in animal models for various neurological diseases including Alzheimer's disease and ischaemic stroke. However, some studies have also reported that HDAC enzymes exert protective effects in sev...

Journal: :BMC Genomics 2021

Abstract Background Genetic aberrations in hepatocellular carcinoma (HCC) are well known, but the functional consequences of such remain poorly understood. Results Here, we explored effect defined genetic changes on transcriptome, proteome and phosphoproteome twelve tumors from an mTOR-driven mouse model. Using Network-based Integration multi-omiCS data (NetICS), detected 74 ‘mediators’ that re...

2018
Shukuan Ling Yuheng Li Guohui Zhong Yongjun Zheng Qing Xu Dingsheng Zhao Weijia Sun Xiaoyan Jin Hongxing Li Jianwei Li Huiyuan Sun Dengchao Cao Jinping Song Caizhi Liu Xinxin Yuan Xiaorui Wu Yinlong Zhao Zizhong Liu Qi Li Yingxian Li

Human cardiovascular system has adapted to Earth's gravity of 1G. The microgravity during space flight can induce cardiac remodeling and decline of cardiac function. At present, the mechanism of cardiac remodeling induced by microgravity remains to be disclosed. Casein kinase-2 interacting protein-1 (CKIP-1) is an important inhibitor of pressure-overload induced cardiac remodeling by decreasing...

2014
Sung Hak Lee Changyoung Yoo Soyoung Im Ji-Han Jung Hyun Joo Choi Jinyoung Yoo

BACKGROUND Histone deacetylase inhibitors are a new class of drugs used in treatment of malignant tumors. Diffuse large B-cell lymphoma (DLBCL) is the most common type of B-cell lymphoma, and it accounts for more than 40% of all B-cell lymphomas. In this study, we aimed to determine the expression patterns of histone deacetylases (HDACs) in DLBCL, to examine whether HDAC expression patterns dif...

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