نتایج جستجو برای: ژن catsper

تعداد نتایج: 15936  

Journal: :The Journal of biological chemistry 2004
Gbolahan W Okunade Marian L Miller Gail J Pyne Roy L Sutliff Kyle T O'Connor Jonathan C Neumann Anastasia Andringa Daniel A Miller Vikram Prasad Thomas Doetschman Richard J Paul Gary E Shull

The relative importance of plasma membrane Ca2+-ATPase (PMCA) 1 and PMCA4 was assessed in mice carrying null mutations in their genes (Atp2b1 and Atp2b4). Loss of both copies of the gene encoding PMCA1 caused embryolethality, whereas heterozygous mutants had no overt disease phenotype. Despite widespread and abundant expression of PMCA4, PMCA4 null (Pmca4-/-) mutants exhibited no embryolethalit...

Journal: :Journal of cell science 2016
Daisuke Yamazaki Haruhiko Miyata Yosuke Funato Yoshitaka Fujihara Masahito Ikawa Hiroaki Miki

Ca(2+) influx triggers sperm capacitation; however, the underlying regulatory mechanisms remain incompletely understood. Here, we show that CNNM4, a Mg(2+) transporter, is required for Ca(2+) influx during capacitation. We find that Cnnm4-deficient male mice are almost infertile because of sperm dysfunction. Motion analyses show that hyperactivation, a qualitative change in the mode of sperm mo...

2014
Christoph Brenker Yu Zhou Astrid Müller Fabio Andres Echeverry Christian Trötschel Ansgar Poetsch Xiao-Ming Xia Wolfgang Bönigk Christopher J Lingle U Benjamin Kaupp Timo Strünker

Sperm are equipped with a unique set of ion channels that orchestrate fertilization. In mouse sperm, the principal K(+) current (IKSper) is carried by the Slo3 channel, which sets the membrane potential (Vm) in a strongly pHi-dependent manner. Here, we show that IKSper in human sperm is activated weakly by pHi and more strongly by Ca(2+). Correspondingly, Vm is strongly regulated by Ca(2+) and ...

Journal: :Physiological reviews 2011
Alberto Darszon Takuya Nishigaki Carmen Beltran Claudia L Treviño

A proper dialogue between spermatozoa and the egg is essential for conception of a new individual in sexually reproducing animals. Ca(2+) is crucial in orchestrating this unique event leading to a new life. No wonder that nature has devised different Ca(2+)-permeable channels and located them at distinct sites in spermatozoa so that they can help fertilize the egg. New tools to study sperm ioni...

Journal: :Human reproduction update 2008
Susan S Suarez

BACKGROUND Sperm hyperactivation is critical to fertilization, because it is required for penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from the oviductal storage reservoir and may propel sperm through mucus in the oviductal lumen and the matrix of the cumulus oophorus. Hyperactivation is characterized by high amplitude, asymmetrical flagellar bending. ...

2016
Kiran Kumar Soni Hye Kyung Kim Bo Ram Choi Keshab Kumar Karna Jae Hyung You Jai Seong Cha Yu Seob Shin Sung Won Lee Chul Young Kim Jong Kwan Park

Cisplatin (CIS) is used in the treatment of cancer, but its nonspecific systemic actions lead to toxic effects on other parts of the body. This study investigated the severity of CIS toxicity by increasing its dose over a constant time period. Sprague Dawley rats were divided into five treatment groups and control group with CIS (2, 4, 6, 8, and 10 mg/kg) administered intraperitoneally for 5 da...

Journal: :Reproduction 2009
Sarah Costello Francesco Michelangeli Katherine Nash Linda Lefievre Jennifer Morris Gisela Machado-Oliveira Christopher Barratt Jackson Kirkman-Brown Stephen Publicover

Intracellular Ca2+ stores play a central role in the regulation of cellular [Ca2+](i) and the generation of complex [Ca2+] signals such as oscillations and waves. Ca2+ signalling is of particular significance in sperm cells, where it is a central regulator in many key activities (including capacitation, hyperactivation, chemotaxis and acrosome reaction) yet mature sperm lack endoplasmic reticul...

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