We present Mapcurves, a quantitative goodness-of-fit (GOF) method that unambiguously shows the degree of spatial concordance between two or more categorical maps. Mapcurves graphically and quantitatively evaluate the degree of fit among any number of maps and quantify a GOF for each polygon, as well as the entire map. The Mapcurve method indicates a perfect fit even if all polygons in one map a...

The homeobox genes ladybird in Drosophila and their vertebrate counterparts Lbx1 genes display restricted expression patterns in a subset of muscle precursors and are both implicated in diversification of muscle cell fates. In order to gain new insights into mechanisms controlling conserved aspects of cell fate specification, we have performed a gain-of-function (GOF) screen for modifiers of th...

Abstract This document reports on the use of an algebraic, visual, formal approach to the specification of patterns for the formalization of the GoF design patterns. The approach is based on graphs, morphisms and operations from category theory and exploits triple graphs to annotate model elements with pattern roles. Being based on category theory, the approach can be applied to formalize patte...

Humans are notoriously poor at assessing future benefits and risks. Consider nuclear power, which was born from a program to develop a weapon of mass destruction. When nuclear power was developed for commercial purposes, the risk was thought to be minimal and no one anticipated the disasters at Three Mile Island, Chernobyl, and Fukushima. On the other hand, no one initially anticipated the bene...

A novel chelating adsorbent was successfully synthesized by cross-linking of 4, 4', 4"-s-triazine-1, 3, 5-triyltri-p-aminobenzoic acid as a linker with nanosheets graphene oxide to provide 3-dimensional framework. Therefore, the adsorption process Cd2+ and Pb2+ on investigated employing an ultrasonic bath. The optimum condition containing small amount (10 mg) for both metals at pH=8 pH=5 Pb2+, ...

The last two and a half years have witnessed a curious debate in virology characterized by a remarkable lack of discussion. It goes by the misleading epithet "gain of function" (GOF) influenza virus research, or simply GOF. As will be seen, there is nothing good to be gained. The controversial experiments confer aerosol transmission on avian influenza virus strains that can infect humans, but w...

Due to the globally increasing share of renewable energy sources like wind and solar power, precise forecasts for weather data are becoming more important. To compute such numerous authors apply neural networks (NN), whereby models became ever complex recently. Using irradiation as an example, we verify if this additional complexity is required in terms forecasting precision. Different NN model...