A previous in vitro investigation found that a sinergistic effect might occur, when using itraconazole (ITRA) and ritonavir (RTV) against Histoplasma capsulatum,1 where an interesting mechanism of action was proposed. However, relevant pharmacokinetic (PK) issues were under explored. Herein, this letter attempts to deepen a clinical PK discussion not performed by Brilhante and colleagues.1 Firs...

The aim of this study was to evaluate the dimensional stability and detail reproduction of two silicones used for facial prosthesis, under the influence of chemical disinfection and storage time. Twenty-eight test specimens were obtained, half made of Silastic MDX 4-4210 silicone, and the other half of Silastic 732 RTV silicone. The test specimens were divided into 4 groups: Silastic 732 RTV an...

Drug-drug interactions (DDIs) with the HIV protease inhibitors (PIs) are complex, paradoxical (e.g., ritonavir/alprazolam), and involve multiple mechanisms. As part of a larger study to better understand these DDIs and to devise a framework for in vitro to in vivo prediction of these DDIs, we determined the inductive effect of ∼2 weeks of administration of two prototypic PIs, nelfinavir (NFV), ...

This paper presents the Slovenian Broadcast News Database project that was started in year 2002 as cooperation between University of Maribor and Slovenian national broadcaster RTV Slovenia. The resulting database will be used for large vocabulary continuous speech recognition and multimedia database retrieval or archive indexation. First some organizational aspects that were needed in initial p...

In recent years, increasing attention has been devoted to electoral turmoil associated with the emergence of new political actors or crisis established parties at national level. However, in multi-level systems, transformations have also affected sub-national politics. This article seeks understand some hitherto unexplored aspects change regional party systems. Change is linked concept instabil...

Abstract Objective Research has demonstrated reaction time variability (RTV) as a potentially sensitive metric for post-concussion assessments. The Brain Gauge Clinical Metrics battery (BG) device uses tactile sensory stimulation to elicit response, increasing accuracy <1 msec versus 30–100 in visually-based (RT) measures. We sought determine if BG RTV could adequately identify individua...