Psoriasis is a chronic inflammatory skin disease, and its immune mechanism has been profoundly elucidated. Biologics targeting interleukin (IL)-23 have prevented the development of psoriasis. As major sources IL-23, dendritic cells (DCs) play pivotal role in psoriasis; however, regulatory IL-23 DCs remains unclear. IL-36γ was reported to reflect disease activity Therefore, we hypothesized that ...

Abstract Graft versus host disease (GVHD) is the major and often lethal complication of allogenic bone marrow transplantation. Prophylactic regimens for GVHD are given as standard pre-transplantation therapy; however, up to 60% these patients develop GVHD, require additional immunosuppressive intervention. We identified a probiotic exopolysaccharide (EPS) that induces inhibitory macrophages tol...

Overenthusiastic repair of damaged blood vessels could cause a fatal blockage. Sedding et al. (page 2801) report that the normal repair-restricting function of factor VII activating protease (FSAP) is disrupted by a common mutation. People carrying the mutation might thus be more at risk of vessel narrowing. Approximately 5% of the population carries an FSAP polymorphism linked to cardiovascula...

acute myeloid leukemia (aml) is a type of poor prognosis hematological malignancies characterized by heterogeneous clonal expansion of myeloid progenitors. leukemic stem cells are thought to form the majority of a cell population in minimal residual diseases (mrds) which are resistant to current chemotherapeutic regimens and mediate disease relapse. current therapeutic vaccine strategies have d...

background: t helper 1 and t helper 17 cells play important roles in immunity against foreign invaders. differentiation of these th subsets is affected by state of maturation and cytokines that are produced by dendritic cells (dcs). curdlan is a linear (1→3)-β- glucan and has shown activity against tumors and infectious agents. objective: this study aims to investigate whether curdlan plays its...