نتایج جستجو برای: پروتئین rkip

تعداد نتایج: 18109  

2008
George Papadopoulos Martin Brown

Parameter estimation plays an important role in Systems Biology in helping to understand the complex behavior of signal transduction networks. The problem becomes more complex as the inherent stochasticity of the signaling mechanism involves noise components of non-Gaussian nature. In this paper a novel stochastic parameter estimation method has been developed where the entropy of the joint res...

2005
Muffy Calder Vladislav Vyshemirsky David Gilbert Richard Orton

We describe a new modelling and analysis approach for signal transduction networks in the presence of incomplete data. We illustrate the approach with an example, the RKIP inhibited ERK pathway [1]. Our models are based on high level descriptions of continuous time Markov chains: reactions are modelled as synchronous processes and concentrations are modelled by discrete, abstract quantities. Th...

2006
David R. Gilbert Monika Heiner

We report on the results of an investigation into the integration of Petri nets and ordinary differential equations (ODEs) for the modelling and analysis of biochemical networks, and the application of our approach to the model of the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signalling pathway. We show that analysis based on a discr...

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