نتایج جستجو برای: پروتئین oprm
تعداد نتایج: 18167 فیلتر نتایج به سال:
Background. Pseudomonas aeruginosa is a causative agent of nosocomial infections. Chloramphenicol broad-spectrum, inexpensive, and common antibiotic. MexAB-OprM secretory pump that causes the innate resistance this bacterium. This study aimed to evaluate expression MexA gene under treatment copper nanoparticles chloramphenicol. Methods. In study, 49 samples were collected from 11 laboratories i...
Stimulation of μ-opioid receptors (OPRMs) brings powerful pain relief, but it also leads to the development of tolerance and addiction. Ensuing withdrawal in abstinent patients manifests itself with severe symptoms, including cold hyperalgesia, often preventing addicted patients from successfully completing the rehabilitation. Unsurprisingly, OPRMs have been a central point of many studies. Non...
Single-cell analysis is a powerful method to assess the heterogeneity among individual cells, enabling the identification of very rare cells with properties that differ from those of the majority. In this Methods Article, we describe the use of a large-scale femtoliter droplet array to enclose, isolate, and analyze individual bacterial cells. As a first example, we describe the single-cell dete...
MexR is a MarR family protein that negatively regulates multidrug efflux systems in the human pathogen Pseudomonas aeruginosa. The mechanism of MexR-regulated antibiotic resistance has never been elucidated in the past. We present here that two Cys residues in MexR are redox-active. They form intermonomer disulfide bonds in MexR dimer with a redox potential of -155 mV. This MexR oxidation leads...
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