Background: Respiratory insufficiency is the most common cause of mortality among patients with a neuromuscular disease. Methods: We explored effects high frequency wall compression and intrapulmonary percussive ventilation, compared standard care or no treatment, on lung volume capacity, quality life in disease during respiratory ...

Background: MicroRNAs are a class of small (~22nt) endogenous RNAs that regulate target transcript expression post-transcriptionally. Previous studies characterized age-related changes in diurnal but it is not understood how these regulated, and whether they may be attributed part to microRNA or activity with age. Diurnal RNA age were previously studied.<ns3:...

Background/objectives: Around 11,500 artificial eyes are required yearly for new and existing patients. Artificial have been manufactured hand-painted at the National Eye Service (NAES) since 1948, in conjunction with approximately 30 local eye services throughout country. With current scale of demand, under significant pressure. Manufacturing delays as well necessar...

Introduction: Faith and systems of beliefs are known to impact not only the emotional, but also immunological state believers in ways that we just starting understand. Moreover, clinical implications previous studies limited. The aim “HEALING” (Hospital-based Ecumenical Linguistic Immuno-NeuroloGic) Study was examine neurological changes hospitalized ...

Background: This report describes the study design and baseline characteristics of patients with Stargardt disease (STGD1) enrolled in STArgardt Remofuscin Treatment Trial (STARTT). Methods: In total, 87 genetically confirmed STGD1 were randomized a double-masked, placebo-controlled proof concept trial to evaluate safety efficacy 2...

Background: Evidence of highly effective repurposed drugs for coronavirus disease 2019 (COVID-19) is insufficient. However, empirical therapy using antiviral, antibiotic and immunomodulatory massive. This study aimed to evaluate the clinical use these outcome hospitalization in COVID-19 patients. Methods: We performed a retrospecti...

Background: Sugar substitutes like maltitol are reported to be noncariogenic ingredients and may not lead the development of dental caries (DC), in contrast sugars other fermentable carbohydrates. The current study aimed investigate effects maltitol-based sugar-free chocolates on factors associated with DC. Methods: This was an ope...

Background: This study was conducted to determine the prevalence of headache in coronavirus disease 2019 (COVID-19) and assess its association as a predictor for COVID-19. also aimed discuss possible pathogenesis COVID-19. Methods: Available articles from PubMed, Scopus, Web Science were searched September 2nd, 2...

The cytotoxicity of Ibaraki virus nonstructural protein NS3 was confirmed, and the contribution of glycosylation to this activity was examined by using glycosylation mutants of NS3 generated by site-directed mutagenesis. The expression of NS3 resulted in leakage of lactate dehydrogenase to the culture supernatant, suggesting the cytotoxicity of this protein. The lack of glycosylation impaired t...

Abstract Background Youth have disproportionately poor HIV outcomes. We aimed to co-design a community-based intervention with youth improve outcomes among 16-24 year-olds, be trialled in Zimbabwe. Methods conducted 90 in-depth interviews youth, family members, community gatekeepers, and hea...