نتایج جستجو برای: پروتئین nrf2

تعداد نتایج: 26324  

2014
Bridgid E. Hast Erica W. Cloer Dennis Goldfarb Heng Li Priscila F. Siesser Feng Yan Vonn Walter Ning Zheng D. Neil Hayes Michael B. Major

NRF2 is a transcription factor that mediates stress responses. Oncogenic mutations in NRF2 localize to one of its two binding interfaces with KEAP1, an E3 ubiquitin ligase that promotes proteasome-dependent degradation of NRF2. Somatic mutations in KEAP1 occur commonly in human cancer, where KEAP1 may function as a tumor suppressor. These mutations distribute throughout the KEAP1 protein but li...

2015
Albena T. Dinkova-Kostova Liam Baird Kira M. Holmström Colin J. Meyer Andrey Y. Abramov

The Kelch-like ECH associated protein 1 (Keap1)-NF-E2 p45-related factor 2 (Nrf2) pathway regulates networks of proteins that protect against the cumulative damage of oxidants, electrophiles and misfolded proteins. The interaction between transcription factor Nrf2 and its main negative cytoplasmic regulator Keap1 follows a cycle whereby the protein complex sequentially adopts two conformations:...

2012
Brian N. Chorley Michelle R. Campbell Xuting Wang Mehmet Karaca Deepa Sambandan Fatu Bangura Peng Xue Jingbo Pi Steven R. Kleeberger Douglas A. Bell

Cellular oxidative and electrophilic stress triggers a protective response in mammals regulated by NRF2 (nuclear factor (erythroid-derived) 2-like; NFE2L2) binding to deoxyribonucleic acid-regulatory sequences near stress-responsive genes. Studies using Nrf2-deficient mice suggest that hundreds of genes may be regulated by NRF2. To identify human NRF2-regulated genes, we conducted chromatin imm...

Journal: :The Journal of biological chemistry 2003
Jong-Min Lee Andy Y Shih Timothy H Murphy Jeffrey A Johnson

NF-E2-related factor-2 (Nrf2) regulates the gene expression of phase II detoxification enzymes and antioxidant proteins through an enhancer sequence referred to as the antioxidant-responsive element (ARE). In this study, we demonstrate that Nrf2 protects neurons in mixed primary neuronal cultures containing both astrocytes ( approximately 10%) and neurons ( approximately 90%) through coordinate...

Journal: :Free radical biology & medicine 2009
Fei Zhao Tongde Wu Alexandria Lau Tao Jiang Zheping Huang Xiao-Jun Wang Weimin Chen Pak Kin Wong Donna D Zhang

The transcription factor Nrf2 has emerged as a master regulator of the endogenous antioxidant response, which is critical in defending cells against environmental insults and in maintaining intracellular redox balance. However, whether Nrf2 has any role in neuronal cell differentiation is largely unknown. In this report, we have examined the effects of Nrf2 on cell differentiation using a neuro...

2016
Liwen Li Hao Pan Handong Wang Xiang Li Xiaomin Bu Qiang Wang Yongyue Gao Guodao Wen Yali Zhou Zixiang Cong Youqing Yang Chao Tang Zhengwei Liu

Venous hypertension(VH) plays an important role in the pathogenesis of cerebral arteriovenous malformations (AVMs) and is closely associated with the HIF-1α/VEGF signaling pathway. Nuclear factor erythroid 2-related factor 2(Nrf2) significantly influences angiogenesis; however, the interplay between Nrf2 and VEGF under VH in brain AVMs remains unclear. Therefore, our study aimed to investigate ...

Journal: :Journal of cell science 2013
Suryakant K Niture Averell Gnatt Anil K Jaiswal

The INrf2 (Keap1)-Nrf2 cell sensor complex has a crucial role in protection against chemical- and radiation-induced oxidative stress and cellular transformation. INrf2, in association with Cul3-Rbx1, ubiquitylates and degrades Nrf2. Exposure to stressors leads to stabilization of Nrf2 and the coordinated activation of cytoprotective proteins and cellular protection. However, the molecular signa...

Journal: :Molecular medicine reports 2012
Hidefumi Sasaki Masayuki Shitara Keisuke Yokota Yu Hikosaka Satoru Moriyama Motoki Yano Yoshitaka Fujii

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a transcription factor belonging to the cap 'n' collar subfamily of the basic-leucine zipper (bZIP) family of transcription factors, which plays a significant role in adaptive responses to oxidative stress. Previously, we reported that NRF2 gene (NFE2L2) mutations correlate with poor prognosis of lung squamous cell carcinomas. We therefore h...

2014
Tao Jiang Fei Tian Hongting Zheng Samantha A. Whitman Yifeng Lin Zhigang Zhang Nong Zhang Donna D. Zhang

The generation of reactive oxygen species has a pivotal role in both acute and chronic glomerular injuries in patients with lupus nephritis. As the transcription factor Nrf2 is a major regulator of the antioxidant response and is a primary cellular defense mechanism, we sought to determine a role of Nrf2 in the progression of lupus nephritis. Pathological analyses of renal biopsies from patient...

2010
Hyo Jin Kang Young Bin Hong Hee Jeong Kim Insoo Bae

Free radicals generated by oxidative stress cause damage that can contribute to numerous chronic diseases. Mammalian cells respond to this damage by increased transcription of cytoprotective phase II genes, which are regulated by NRF2. Previously, it has been shown that NRF2 protein levels increase after oxidative stress because its negative regulator, KEAP1, loses its ability to bind NRF2 and ...

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