نتایج جستجو برای: پروتئین bdnf

تعداد نتایج: 26807  

2010
Indrek Koppel Tamara Aid-Pavlidis Kaur Jaanson Mari Sepp Kaia Palm Tõnis Timmusk

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family of neurotrophic factors, has important functions in the peripheral and central nervous system of vertebrates. We have generated bacterial artificial chromosome (BAC) transgenic mice harboring 207 kb of the rat BDNF (rBDNF) locus containing the gene, 13 kb of genomic sequences upstream of BDNF exon I, and 144 kb downst...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Scott Gehler Alisa E Shaw Patrick D Sarmiere James R Bamburg Paul C Letourneau

The molecular mechanisms by which neurotrophins regulate growth cone motility are not well understood. This study investigated the signaling involved in transducing BDNF-induced increases of filopodial dynamics. Our results indicate that BDNF regulates filopodial length and number through a Rho kinase-dependent mechanism. Additionally, actin depolymerizing factor (ADF)/cofilin activity is neces...

2017
Chanjuan Zhou Jiaju Zhong Bin Zou Liang Fang Jianjun Chen Xiao Deng Lin Zhang Xiang Zhao Zehui Qu Yang Lei Ting Lei

BACKGROUND Brain derived neurotrophic factor (BDNF) is one of the most important regulatory proteins in the pathophysiology of major depressive disorder (MDD). Increasing numbers of studies have reported the relationship between serum/plasma BDNF and antidepressants (ADs). However, the potential effects of several classes of antidepressants on BDNF concentrations are not well known. Hence, our ...

Journal: :Open Journal of Clinical Diagnostics 2022

Purpose: Adolescent idiopathic scoliosis is a condition characterized by three-dimensional curvature of the spine. However, in addition to spinal curvature, it has also been reported that patients with can display other abnormal physiologic parameters, such as hormone imbalances, genetic variants, and micronutrient deficiencies. The present study evaluated salivary progesterone levels, well res...

2015
Pengzhou Hang Jing Zhao Benzhi Cai Shanshan Tian Wei Huang Jing Guo Chuan Sun Yue Li Zhimin Du

BACKGROUND Brain-derived neurotrophic factor (BDNF) is associated with coronary artery diseases. However, its role and mechanism in myocardial infarction (MI) is not fully understood. METHODS Wistar rat and Kunming mouse model of MI were induced by the ligation of left coronary artery. Blood samples were collected from MI rats and patients. Plasma BDNF level, protein expression of BDNF, tropo...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2006
Hong Wang Shyue-an Chan Michael Ogier David Hellard Qifang Wang Corey Smith David M Katz

Disruptions in brain-derived neurotrophic factor (BDNF) expression are proposed to contribute to the molecular pathogenesis of Rett syndrome (RTT), a severe neurological disorder caused by loss-of-function mutations in methyl-CpG-binding protein-2 (MeCP2). Although MeCP2 is a transcriptional regulator of BDNF, it is unknown how MeCP2 mutations affect transsynaptic BDNF signaling. Our findings d...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Anthony G Lau Hasan A Irier Jiaping Gu Donghua Tian Li Ku Guanglu Liu Mingjing Xia Brita Fritsch James Q Zheng Raymond Dingledine Baoji Xu Bai Lu Yue Feng

Expression of the brain-derived neurotrophic factor (BDNF) is under tight regulation to accommodate its intricate roles in controlling brain function. Transcription of BDNF initiates from multiple promoters in response to distinct stimulation cues. However, regardless which promoter is used, all BDNF transcripts are processed at two alternative polyadenylation sites, generating two pools of mRN...

2008
Bruno Bariohay Catherine Tardivel Juliette Pio André Jean Bernadette Félix

Brain-derived neurotrophic factor (BDNF) acts as an anorexigenic factor in the dorsal vagal complex (DVC) of the adult rat brainstem. The DVC contains the premotoneurons controlling swallowing, a motor component of feeding behavior. Although rats with transected midbrain do not seek out food, they are able to swallow and to ingest food. Because BDNF and Tropomyosin-related kinase B receptors (T...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Maria José Diógenes Catarina Cunha Fernandes Ana Maria Sebastião Joaquim Alexandre Ribeiro

Both brain-derived neurotrophic factor (BDNF) and adenosine influence neuronal plasticity. We now investigated how adenosine influences the action of BDNF on synaptic transmission in the CA1 area of the rat hippocampal slices. Alone, BDNF (20-100 ng/ml) did not significantly affect field EPSPs (fEPSPs). However, a 2 min pulse of high-K(+) (10 mm) 46 min before the application of BDNF (20 ng/ml)...

Journal: :Journal of neurocytology 2004
Irina V Nosrat Karin Agerman Andrea Marinescu Patrik Ernfors Christopher A Nosrat

Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) are members of the neurotrophin family and are expressed in the developing and adult tongue papillae. BDNF null-mutated mice exhibit specific impairments related to innervation and development of the gustatory system while NT-3 null mice have deficits in their lingual somatosensory innervation. To further evaluate the functional...

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