Surface enhanced Raman spectroscopy (SERS) has been widely investigated as an effective technique for low-concentration bio-chemical molecules detection. A rapid two-step approach to fabricate SERS substrates with high controllability in ambient air is developed. Dynamic laser ablation directly creates microgroove on the Si substrate. Meanwhile, nanoparticles are synthesized via the nucleation ...

A microfluidic device with integrated silver nanoparticles (AgNPs) was fabricated via in situ galvanic replacement of a pre-patterned copper substrate in a microfluidic channel. The integrated microfluidic device with AgNPs serves as a highly active Raman substrate which can be applied for in-channel surface-enhanced Raman scattering (SERS). Preparation of the SERS active substrate and subseque...

Chemical sensing on the nanoscale has been breaking new ground since the discovery of surface enhanced Raman scattering (SERS). For nanoparticles, controlled particle aggregation is necessary to achieve the largest SERS enhancements. Therefore, aggregating agents such as salts or linker molecules are used in conjunction with chemically sensitive reporters in order to develop robust environmenta...

Graphene oxide (GO) is an emerging material for surface-enhanced Raman scattering (SERS) due to its strong chemical enhancement. Studying the SERS performance of plasmonic nanoparticle/GO hybrid materials at the single particle level is crucial for direct probing of the chemical effect of GO on plasmonic nanoparticles. In this work, we integrate GO and shape-controlled Ag nanoparticles to creat...

The first observations of the Raman spectra of pyridine on roughened silver were made in 19741; however, at this time the authors did not recognize that these spectra were due to any unusual, enhanced, or new phenomena. Since its discovery in 19772, interest in and the use of surface enhanced Raman spectroscopy (SERS) has grown exponentially (Fig. 1). The SERS field has dramatically progressed ...

We demonstrate label-free detection of lipid vesicles and polystyrene beads freely diffusing in aqueous solution using surface enhanced Raman scattering (SERS). The signals observed enable real-time identification and monitoring of individual particles interacting with the SERS substrate. SERS is demonstrated as a label-free method capable of monitoring transient species in solution on the mill...

Here we report on the synthesis and averaged SERS measurements of multi-shell nanomatryoshka SERS tags. By tuning the number of shells or by changing the Raman reporters in different gap layers, their Raman intensities and spectral bands were tunable. These tags show great potential for SERS-based biosensing and bioimaging.

Iodide adsorption and electrochemical negative potential desorption were proposed and compared to obtain clean SERS substrates. The two methods can effectively eliminate the interference of surface impurities in the SERS detection. SERS signals of membranes of living cells with a good reproducibility have been obtained.

Prepared by simple pour and mix chemistry, gold nanosponges (AuNS) are versatile structures for surface-enhanced Raman spectroscopy (SERS). An investigation into the enhancement is performed by relating the nanostructure's morphology to the SERS signal. The potential of the AuNS in SERS-based molecular and biomolecular detection is introduced.

This communication reports, for the first time, the dependence of the SERS intensities under resonant CT conditions (SERS-CT) on the electrode potential. SERS-CT intensities have been estimated from the properties of S(0)-CT(i) transitions ranging between 200-1200 nm of selected [Ag(n)-pyridine](q) and [Ag(n)-pyrazine](q) complexes.