The influence of ß-dihydroxyl groups in the alkaline hydrolysis of glucosidic bonds is examined. In deriva­ tives of ß-D-glucopyranosides, all hydroxyl groups are trans to each other, and the alkaline elimination of sub­ stituted methyl ethers in positions C-2 and C-4 can be explained, in part, by assistance from neighboring trans a-hydroxyls. The rate of degradation of ethyl 2-2-methyl-ß-D-glu...

Background: Wet cupping therapy is a complementary therapy in pain management. The mechanism of this therapy, however, needs further elucidation. Cells injured by wet cupping therapy seem to stimulate the expression of heat shock protein 70 (HSP70). Its benefit in pain reduction could be mediated by the expression of ß-endorphin. This study aimed at determining the correlation between HSP70 and...

Background: Some types of implants used for orbital implantation have side effects and complications. In this study we have evaluated beta-tricalcium phosphate (ß-TCP: ChronOS) granules as an orbital implant. Methods: Eighteen rabbits randomly allocated to four groups. Right eye enucleation performed in groups I to III followed by filling with autologous bone particles (n=5), a mixture of autol...

The concept of symmetric recursive algorithm leads to new, sdimensional spline spaces. We present a general scheme for constructing a collection of multivariate S-splines with k-l continuous derivatives whose linear span contains all polynomials of degree at most k . This scheme is different from the one developed earlier by Dahmen and Micchelli and, independently, by Höllig, which was based on...

Enzyme linked immunosorbent assay (ELISA) for ß 2 -Glycoprotein I dependent anticardiolipin antibodies (ß 2 I aCL) was carried out in 82 women experiencing 3 or more recurrent pregnancy losses and 82 normal healthy controls. The mean aCL levels were 14.53 (μ/ml) ± 16.22 in women with repeated abortions and 7.26 (μ/ml) ± 3.65 in controls. The difference in the values between the two groups was f...

Background Both short and long sleep duration were previously associated with incident dementia, but underlying mechanisms of this association remains unknown. This project aims to evaluate how self-reported its change over time associate (A)myloid, (T)au, (N)eurodegeneration (V)ascular neuroimaging markers Alzheimer’s disease (AD). Method Within the Framingham Heart Study, two samples studied:...

Transforming growth factor-ß (TGF-ß) signaling is implicated in the pathogenesis of fibrosis in scleroderma or systemic sclerosis (SSc), but the precise mechanisms are poorly understood. The immediate-early gene Egr-1 is an inducible transcription factor with key roles in mediating fibrotic TGF-ß responses. To elucidate Egr-1 function in SSc-associated fibrosis, we examined change in gene expre...