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به منظور مطالعۀ عملکرد ژنهای f3´5´h و f3´h وبرهمکنش آن ها در مسیر بیوسنتز فلاونوئیدها در انگور، از طریق طراحی و ساخت سازه های مناسب ایجاد کنندۀ ihprna، لاین های تراریخت حاوی سازۀ خاموش کنندۀ ژن f3´h وسازۀ خاموشکنندۀ هر دو ژن f3´5´h و f3´h ایجاد شدند. به این منظور قطعاتی از دو ژن انتخاب و به صورت تکرارهای معکوس در ناقل phannibal درج و با بهره گیری از سیستم ناقل دوگانه، هر یک از سازه های تهیه ش...
چکیده ندارد.
Five novel peptides were identified in the brains of mice lacking active carboxypeptidase E, a neuropeptide-processing enzyme. These peptides are produced from a single precursor, termed proSAAS, which is present in human, mouse, and rat. ProSAAS mRNA is expressed primarily in brain and other neuroendocrine tissues (pituitary, adrenal, pancreas); within brain, the mRNA is broadly distributed am...
Transition-state analogues of bacterial 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases (MTANs) disrupt quorum-sensing pathways in Escherichia coli and Vibrio cholerae, demonstrating the potential to limit pathogenicity without placing bacteria under intense selective pressure that leads to antibiotic resistance. Despite the similarity of the crystal structures of E. coli MTAN (EcMT...
An organocatalytic strategy for the synthesis of tetrasubstituted pyrrolidines with monoactivated azomethine ylides in high enantiomeric excess and excellent exo/endo selectivity is presented. The key to success is the intramolecular activation via hydrogen bonding through an o-hydroxy group, which allows the dipolar cycloaddition to take place in the presence of azomethine ylides bearing only ...
SUMMARY The drugs [1-ß-D-arabinofuranosylcytosine (ara-C), hy-droxyurea (HU), 5-hydroxy-2-formylpyridine thiosemicar-bazone (5-HP), and camptothecin sodium salt (camptothecin)] considered in this paper markedly inhibit DNA synthesis and are maximally cytotoxic to cells in S phase. In these studies, high-specific-activity thymidine-3H (HSA-TdR-3H) was used as a control compound which killed cel...
The shortcomings of the Standard Big Bang Cosmological Model as well as their resolution in the context of inflationary cosmology are discussed. The inflationary scenario and the subsequent oscillation and decay of the inflaton field are then studied in some detail. The density perturbations produced during inflation and their evolution during the matter dominated era are presented. The tempera...
Based on the joined work performed together with Z. Bern, D. Forde, and D. Kosower [1], in this talk it is recalled the (twistor-motivated) diagrammatic formalism describing tree-level scattering amplitudes presented by Cachazo, Svrček and Witten, and it is discussed an extension of the vertices and accompaining rules to the construction of vector-boson currents coupling to an arbitrary source....
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