Anatomical resection (AR) has been reported to achieve better long-term outcomes than non-anatomical for the treatment of hepatocellular carcinoma (HCC). The surgical feasibility and oncological significance laparoscopic AR (LAR), especially “subsegment resection”, “cone unit repeat LAR HCC, remain unproven. We present a 67-year-old patient with alcoholic liver cirrhosis HCC who underwent full ...

BACKGROUND AND AIMS Deletions/mutations in the hepatitis B virus (HBV) pre-S region have been associated with hepatocellular carcinoma (HCC). We aimed to study the evolutionary changes of pre-S mutations prior to HCC development. METHODS We studied the HBV pre-S sequences at 1 to 10 years preceding diagnosis of HCC in 74 patients with HBV-related HCC (HCC group). 148 chronic hepatitis B patie...

BACKGROUND Mixed fibrolamellar hepatocellular carcinoma (mFL-HCC) is a rare liver tumor defined by the presence of both pure FL-HCC and conventional HCC components, represents up to 25% of cases of FL-HCC, and has been associated with worse prognosis. Recent genomic characterization of pure FL-HCC identified a highly recurrent transcript fusion (DNAJB1:PRKACA) not found in conventional HCC. P...

The G protein-coupled receptor, class C, group 5, member A (GPRC5A) plays a key role in various diseases, but its effect on hepatocellular carcinoma (HCC) and the potential underlying mechanisms remains unclear. In present study, we explored of GPRC5A progression HCC further mechanism action. results revealed that expression was lower tissues cells. Overexpression suppressed proliferation epith...

Inguinal hernias are common diseases, but malignant lesions in groin rare; metastatic hepatocellular carcinoma (HCC) the hernia sac is extremely rare. We report a 72-year-old man who had advanced stage HCC with portal vein invasion and multiple lymphadenopathies. He presented painless palpable mass right groin. Computed tomography scan showed contrast-enhanced soft tissue (2.8 cm size) at herni...

Background and AimsThe growing knowledge of ferroptosis has suggested the regulatory role in hepatocellular carcinoma (HCC), but pertinent molecular mechanisms remain unclear. Herein, this study investigated mechanistic basis ferroptosis-related genes (ferrGenes) growth HCC.

Abstract Background Hepatocellular carcinoma (HCC) represents the sixth most common cancer worldwide and fourth in Egypt. Persistent inflammation specific somatic mutations driving genes play a major role development of HCC. One these is CTNNB1 with subsequent activation β-catenin HCC, associated risk malignant transformation. In this study, we investigate clinical utility peripheral blood circ...

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is becoming a leading cause of chronic liver disease. Hepatocellular carcinoma (HCC) is one of its complications. Although the pathophysiology is unclear, it is reasonable to expect that cryptogenic cirrhosis related HCC (cryptogenic HCC) behaves differently to other types of HCC. This study prospectively compared patients with cryptogenic HC...