The current study was undertaken to define a biological role for the endothelin-A receptor in a clinically relevant model of altered systemic and renal function produced by suprarenal aortic cross-clamping. This model is associated with profound systemic and renal vasoconstriction, acute renal failure, and a significant increase in circulating endothelin. Studies were performed in three groups ...

BACKGROUND Lack of intra-operative haptic information during robotic surgery increases the risk for unintended tissue overload and damage. Knowledge about the acute and chronic fundamental relationship between force load and induced damage in healthy and diseased arteries is crucial to enable intra-operative haptic feedback or shared autonomy and improve patient safety. METHODS Arteries of wi...

In the process of tightening up and screwing off the iron roughneck, it is required that the center of clamping pliers and the center of drill pipe are coincident, so as to avoid the damage of the circular guide in clamping system, and to ensure the iron roughneck work normally. While the traditional method of centering is artificial in iron roughneck, its precision is low, so it is easy to dam...

We investigate the role of weak clamping forces, typically assumed to be infinite, in carbon nanotube mechanical resonators. Due to these forces, we observe a hysteretic clamping and unclamping of the nanotube device that results in a discrete drop in the mechanical resonance frequency on the order of 5-20 MHz, when the temperature is cycled between 340 and 375 K. This instability in the resona...

Bispectral index (BIS) monitoring is commonly used to provide a measure of depth during general anaesthesia in attempt to reduce the rare occurrence of awareness [1,2]. The Bispectral Index is a generated number between 0 and 100 that is derived through utilization of a number of advanced EEG signal processing techniques including bispectral analysis, power spectral analysis, and time domain an...

BACKGROUND Paraplegia is a devastating complication for patients undergoing repair of thoracoabdominal aortic aneurysms. A monitor to detect spinal cord ischemia is necessary if anesthesiologists are to intervene to protect the spinal cord during aortic aneurysm clamping. METHODS The medical records of 60 patients who underwent thoracoabdominal aortic aneurysm repair with regional lumbar epid...

Postoperative renal and other ischemic complications due to atheroembolization after clamping of the proximal site of an abdominal aortic aneurysm are catastrophic. We present here a method of débridement of atheroma and clamping under hypothermic circulatory arrest to avoid iatrogenic atheroembolization.