The more one has to deal with the great problem of mental defect and its problems the less anxious one is to say anything at all. One always feels that the really helpful speakers at Mental Deficiency Conferences have been brought there under the persuasion of a revolver. The reason is because people who are doing things or trying to do things are apt to be very diffident and reticent until the...

This study describes the first instance of the use of two differently sized Au nanoparticles (Au NPs), acting separately as donor and acceptor, in homogeneous photoluminescence quenching assays developed for the analysis of proteins. Introduction of a breast cancer marker protein, platelet-derived growth factor AA (PDGF AA), to a solution of 11-mercaptoundecanoic acid-protected, 2.0-nm photolum...

BACKGROUND Whether all-polyethylene tibial (APT) components are beneficial to patients who received distal femur limb-salvage surgery lacks high-quality clinical follow-up and mechanical evidence. This study aimed to investigate the biomechanics of the distal femur reconstructed with APT tumor knee prostheses using finite element (FE) analysis based on our previous, promising clinical outcome. ...

Staphylococcus aureus (S. aureus) is an important human pathogen that causes several diseases ranging from superficial skin infections to life-threatening diseases. Here, a method combining positive dielectrophoresis (pDEP) driven on-line enrichment and aptamer-fluorescent silica nanoparticle label has been developed for the rapid and sensitive detection of S. aureus in microfluidic channels. A...

A group of 29 college students who had been arrested or nominated as having participated in a street disturbance aimed at producing social change were interviewed. The interview schedule was highly similar to one which had been used to investigate attitudes toward violence in a random, representative sample of American men. The data collected from the arrestees are compared with data from colle...

This project (10) evaluated audible pedestrian traffic signals (APTS) from three perspectives: 1) the patterns of use and the impact of these signals on pedestrian travel; 2) the physical characteristics of the sound emitted by the Nagoya/Traconex APTS; and, 3) the detectability of the sounds emitted by this brand of APTS. This paper, the last of three companion articles (13,14), describes the ...

Introduction: In the present study, AS1411 aptamer conjugated gold nanoclusters (GNCs) have been introduced as a targeted radiosensitizer for enhancing megavoltage radiation therapy efficacy. RT has identified as an effective therapeutic modality for many different types of solid tumors. However, equal radiation beams absorption by tumor and surrounding healthy tissues is still...

Ligand-mediated prostate cancer (PCa)-targeting gene delivery is one of the focuses of research in recent years. Our previous study reported the successful preparation of aptamer-modified nanoparticles (APT-NPs) in our laboratory and demonstrated their PCa-targeting ability in vitro. However, the mechanism underlying this PCa-targeting effect and their anticancer ability in vivo have not yet be...

BACKGROUND This study evaluated the diagnostic performance of the atopy patch test (APT) compared with skin prick testing (SPT) and in vitro IgE measurement in a large group of patients with atopic dermatitis (AD) with or without respiratory symptoms (RS). METHODS The study included 521 patients (292 males, 229 females; age, 0.5-18 years; median age, 6 years) with AD and RS with different cli...

Advanced Persistent Threat (APT) attackers apply multiple sophisticated methods to continuously and stealthily steal information from the targeted cloud storage systems and can even induce the storage system to apply a specific defense strategy and attack it accordingly. In this paper, the interactions between an APT attacker and a defender allocating their Central Processing Units (CPUs) over ...