The recent description of an early T-lineage progenitor (ETP) population in adult mouse thymus implies the presence of a bone marrow predecessor that has not yet been identified. Here we describe a Lin Neg Sca-1 Pos c-kit Hi Thy-1.1 Neg L-selectin Pos adult mouse bone marrow population that resembles the thymic ETP in both antigen expression phenotype and post-transplant lineage potential. Thes...

Since its very appearance, probably thanks to its provocative name, new economic geography (NEG) has stirred a debate on whether it is economic geography proper or rather geographical economics. In both cases, its real novelty has been questioned. We focus on this last issue. In particular, we argue that many NEG ideas have been around for a long time in the works of economic geographers and lo...

Loss of functional retinal ganglion cells (RGC) is an element of retinal degeneration that is poorly understood. This is in part due to thelack of a reliable and validated protocol for the isolation of primary RGCs. Here, we optimize a feasible, reproducible, standardizedflow cytometry-based protocol for the isolation and enrichment of homogeneous RGC with the Thy1.2hiCD48ne...

Chronic inflammation is associated with promotion of malignancy and tumor progression. Many tumors enhance the accumulation of myeloid-derived suppressor cells (MDSC), which contribute to tumor progression and growth by suppressing anti-tumor immune responses. Tumor-derived IL-1β secreted into the tumor microenvironment has been shown to induce the accumulation of MDSC possessing an enhanced ca...

Abstract In 2016, Béziau introduces a restricted notion of paraconsistency, the so-called genuine paraconsistency. A logic is paraconsistent if it rejects laws $\varphi ,\neg \varphi \vdash \psi $ and $\vdash \neg (\varphi \land )$. that paper, author analyzes, among three-valued logics, which them satisfy this property. If we consider multiple-conclusion consequence relations, dual properties ...