نتایج جستجو برای: میکروlet 7a rna

تعداد نتایج: 253422  

2002
E. J. Stellwag P. B. Hylemon

The rate of 7a-dehydroxylation of primary bile acids was quantitatively measured radiochromatographically in anaerobically washed whole cell suspensions of Clostridium leptum. The pH optimum for the 7a-dehydroxylation of both cholic and chenodeoxycholic acid was 6.5-7.0. Substrate saturation curves were observed for the 7a-dehydroxylation of cholic and chenodeoxycholic acid. However, cholic aci...

Journal: :Journal of virology 2004
Yee-Joo Tan Burtram C Fielding Phuay-Yee Goh Shuo Shen Timothy H P Tan Seng Gee Lim Wanjin Hong

Besides genes that are homologous to proteins found in other coronaviruses, the severe acute respiratory syndrome coronavirus genome also contains nine other potential open reading frames. Previously, we have characterized the expression and cellular localization of two of these "accessory" viral proteins, 3a (previously termed U274) and 7a (previously termed U122). In this study, we further ex...

2017
Bin Zhao Yu-Lin Lu Yong Yang Li-Bing Hu Yu Bai Rui-Qian Li Guo-Ying Zhang Jun Li Cheng-Wei Bi Li-Bo Yang Chen Hu Yong-Hong Lei Qi-Lin Wang Zhi-Min Liu

Long non-coding RNAs (lncRNAs) were playing critical roles in tumorigenesis. However, in prostate cancer, the roles and mechanisms of lncRNAs especially ANRIL were largely unknown. We investigated the effects of ANRIL on the proliferation and migration of prostate cancer cells using CCK-8 assay and Transwell migration assay. Real-time PCR and western blotting assays were used to analyze the lev...

2017
Massimo Re Giuseppe Magliulo Federico M Gioacchini Arisa Bajraktari Andrea Bertini Artan Çeka Corrado Rubini Luigi Ferrante Antonio D Procopio Fabiola Olivieri

OBJECTIVE Altered microRNAs (miRNAs) expression has been found in many cancer types, including laryngeal squamous cell carcinoma (LSCC). The aim of this study was to determine the role and clinical value of three LSCC-related miRs, such as miR-21-5p, miR-let-7a, and miR-34c-5p in a homogeneous cohort of patients with primary LSCC treated by primary surgery. METHODS Expression levels of miR-21...

Journal: :Journal of virology 1985
T C Mettenleiter N Lukàcs H J Rziha

The unique short (Us) region of the pseudorabies virus (PRV) genome, which displays high transcriptional activity during the late phase of infection and has been found to code for glycoproteins, is partially deleted in the genomes of three vaccine strains (A57, Norden, and NIA-4). This deletion is located in the SalI subfragment 7A of BamHI fragment 7. To identify possible viral gene products i...

2014
Mei-hua Bao Yi-wen Zhang Xiao-ya Lou Yu Cheng Hong-hao Zhou David Jourd'heuil

Lectin-like low-density lipoprotein receptor 1 (LOX-1) is a receptor for oxidized low density lipoprotein (oxLDL) in endothelial cells. The activation of LOX-1 by oxLDL stimulates the apoptosis and dysfunction of endothelial cells, and contributes to atherogenesis. However, the regulatory factors for LOX-1 are still unclear. MicroRNAs are small, endogenous, non-coding RNAs that regulate gene ex...

2014
Pauline W. Ondachi Ana H. Castro Jakub M. Bartkowiak Charles W. Luetje M. Imad Damaj S. Wayne Mascarella Hernán A. Navarro F. Ivy Carroll

2'-Fluoro-3-(substituted pyridine)epibatidine analogues 7a-e and 8a-e were synthesized, and their in vitro and in vivo nAChR properties were determined. 2'-Fluoro-3'-(4″-pyridinyl)deschloroepibatidine (7a) and 2'-fluoro-3'-(3″-pyridinyl)deschloroepibatidine (8a) were synthesized as bioisosteres of the 4'-nitrophenyl lead compounds 5a and 5g. Comparison of the in vitro nAChR properties of 7a and...

Journal: :Small 2014
Perry T Yin Birju P Shah Ki-Bum Lee

A novel therapy is demonstrated utilizing magnetic nanoparticles for the dual purpose of delivering microRNA and inducing magnetic hyperthermia. In particular, the combination of lethal-7a microRNA (let-7a), which targets a number of the survival pathways that typically limit the effectiveness of hyperthermia, with magnetic hyperthermia greatly enhances apoptosis in brain cancer cells.

2012
N. Subhakara Reddy A. Srinivas Rao M. Adharvana Chari V. Ravi Kumar V. Jyothi V. Himabindu

Synthesis and antibacterial activity of some novel urea and thiourea derivatives (7a-7k, 8a-8f) of anacardic acid prepared from commercially available anacardic acid which is obtained from natural product Cashew Nut Shell Liquid (CNSL). Compounds (7a-7k, 8a-8f) were tested for Gram positive and Gram negative bacterial cultures. Most of the compounds were showed active compared with standard dru...

Journal: :Molecules 2007
Bilkish Rahman Hiroki Akutsu Jun-ichi Yamada Shin'ichi Nakatsuji

Three kinds of molecular complexes based on tetrathiafulvalene (TTF) and dialkylviologens were prepared and their crystal structures elucidated. While TTF-dimethylviologen complex forms a mixed stack arrangement of donors and acceptors in its crystal structure, TTF donors aggregate with long alkyl groups by CH/pi and/or van der Waals interactions in a couple of TTF-heptylviologen complexes.

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