Geldanamycin (GM) is a natural antibiotic that binds Hsp90 and induces the degradation of receptor tyrosine kinases, steroid receptors, and Raf. It is a potent inhibitor of cancer cells that overexpress HER-kinases, but its effects on other important proteins may cause significant toxicity and limit its clinical use. We report the synthesis and identification of a GM dimer, GMD-4c, which had se...

C ystic fibrosis–related diabetes (CFRD) is considered the most common comorbidity in patients affected by cystic fibrosis (CF), with a prevalence increasing with age (1). Recently, more attention has been turned to other less severe glucose metabolism derangements (GMD), since prediabetes may be related to increased morbidity (1), and early treatment may improve the clinical course in patients...

MERIT (“Multimedia Extensions of Retrieval Interaction Tools”) provides a user centered interface to a database covering research programs, projects, and consortia in the field of information technology. The system supports the user by offering a selection of sample retrieval strategies – called cases – which are modifiable to meet situative requirements. Then the system is able to offer a situ...

INTRODUCTION Due to dearth of data, chronic kidney disease (CKD) outcome in African children has been dismal owing to poor understanding of its etiology, manifestations and management. METHODS We retrospectively analyzed the records of 154 CKD children and adolescents who were managed at Obafemi Awolowo University Teaching Hospitals Complex between 2000 and 2009 to evaluate the epidemiology a...

Hybrid precoding can significantly reduce the number of required radio frequency (RF) chains and relieve the huge energy consumption in mmWave massive MIMO systems, thus attracting much interests from academic and industry. However, most existing hybrid precoding schemes are based on singular value decomposition (SVD). Due to the very different subchannel signal-to-noise ratios (SNRs) after SVD...

The problem of selecting critical examples for training neural networks is discussed. Based on Bayesian statistics and information theory we derive a measure of criticality and present a computationally efficient method for selecting critical examples. This leads to a new type of learning scheme in which the network is trained incrementally on an increasing number of self-selected examples, ins...

Background Gastrointestinal (GI) symptoms are common in the general population. This investigation studied the effects of Carthami flos (CF), a natural product, on GI motility. Methods We checked the intestinal transit rates (ITRs) or gastric emptying in normal and in GI-motility-dysfunction (GMD) mice in vivo. The GMD mice were made by acetic acid or streptozotocin. Results Both ITRs and g...