AIMS To establish whether adolescent orthodontic patients with hypodontia have a preference between the aesthetic outcomes of two treatment strategies for lateral incisor agenesis. MATERIALS/METHODS Standardized photographs of pre-orthodontic patients with missing lateral incisors were manipulated to produce images that represented space opening and tooth replacement in the lateral incisor sp...

Here we report on the clinical findings and key symptoms in WNT10A-related ectodermal dysplasias. The ectodermal dysplasias (ED) are a large, heterogeneous group of disorders characterized by defects in the morphogenesis of skin, sweat, sebaceous, submucous, and mammary glands, hair, nails and teeth. Numerous more or less distinct entities have been reported, however, most of them are very rare...

Case report A 3-year-old boy was seen at the Department of Maxillo-Facial Surgery and Paediatric Dentistry of the Children’s Hospital of Trieste. The multi-systemic features of XLPDR included a number of oro-dental manifestations such as misshapen teeth, scissor bite, swallowing difficulties, agenesis of the 4 permanent second premolars, taurodontism, early resorption of deciduous roots, and pr...

In the now broad field of human dental genetics, variations in the number of permanent teeth have attracted repeated attention. Indeed, of articles dealing with population frequencies, pedigree analysis, or estimates of hereditability, the greatest number have been concerned with missing or supernumerary teeth.'-4 It is not difficult to understand why such tooth number polymorphisms have preemp...

Neuroblastoma, a malignant tumor of the sympathetic nervous system and the most common extracranial solid tumor in childhood, arises from embryonic neural crest cells. Tooth development begins before birth and continues for 12–14 years with the development of the third molar for several years. Abnormal events that occur during odontogenesis give permanent damage. Whereas the impact of multimoda...

A genome-wide association study (GWAS) identifies regions of the genome that likely affect the variable state of a phenotype of interest. These regions can then be studied with population genetic methods to make inferences about the evolutionary history of the trait. There are increasing opportunities to use GWAS results – even from clinically-motivated studies – for tests of classic anthropolo...