The notion of recurrence over continuous or dense time, as required for expressing analog and mixed-signal behaviors, is fundamentally different from what offered by the operators SystemVerilog assertions (SVAs). This article introduces formal semantics time provides a methodology runtime verif...

Specific cell targeting with one site-specific recombinase is challenging. In this issue of Cell Stem Cell, Han et al., 2021Han X. Zhang Z. He L. Zhu H. Li Y. Pu W. M. Zhao Liu K. al.A suite new Dre drivers markedly expands the ability to perform intersectional genetic targeting.Cell Cell. 2021; 28: 1160-1176Abstract Full Text PDF PubMed Scopus (36) Google Scholar released a collection and demo...

BACKGROUND Aminosilane-coated iron oxide nanoparticles (AmS-IONPs) have been widely used in constructing complex and multifunctional drug delivery systems. However, the biocompatibility and uptake characteristics of AmS-IONPs in central nervous system (CNS)-relevant cells are unknown. The purpose of this study was to determine the effect of surface charge and magnetic field on toxicity and upta...

Receptors for advanced glycation end-products (RAGE) are multiligand cell surface receptors of the immunoglobin family expressed by epithelium and macrophages, and expression increases following exposure to cigarette smoke extract (CSE). The present study sought to characterize the proinflammatory contributions of RAGE expressed by alveolar macrophages (AMs) following CSE exposure. Acute exposu...

BACKGROUND Acute mountain sickness (AMS) refers to the cerebral abnormalities typically triggered by exposure to hypobaric hypoxia at high altitude. Although AMS is not often life threatening, it can seriously impact health quality and decrease productivity. Thus, detection of potential susceptibility to AMS has become important for people arriving at high-altitude plateaus for the first time, ...

Altitude illness remains a major cause of mortality. Reduced chemosensitivity, irregular breathing leading to central apnoeas/hypopnoeas, and exaggerated pulmonary vasoconstriction may compromise oxygenation. All factors could enhance susceptibility to acute mountain sickness (AMS). We compared 12 AMS-susceptible individuals with recurrent and severe symptoms (AMS+) with 12 "AMS-nonsusceptible"...

Inorganic components were measured in the aged ambient aerosols from Cape Hedo, Okinawa, an outflow region of East Asia, using online quadrupole Aerodyne aerosol mass spectrometer (Q-AMS) and offline ion chromatography (IC) Sunset Lab carbon analyzer. Here, we performed inter-comparison study on nitrate (NO3−), ammonium (NH4+) sulfate (SO42−) that by IC AMS. Sulfate showed a good agreement betw...

Attainable moment sets (AMS) are a powerful method to assess aircraft controllability. However, as attainable only take into account the achievable set of control effectors, they do not required fulfill mission requirements. This paper proposes calculate corresponding (RMS) which defines moments sufficient for fulfilling controllability requirements in flight envelope. The applies approach nonl...

Prolonged and improper usage of antibiotics has been shown as a main reason for the emergence multidrug-resistant pathogens.Antimicrobial stewardship (AMS) programs have to reduce rate resistance. De-escalation antimicrobials is an important component AMS. AMS programmes require regular auditing feedback proper implementation continuous improvement. Hence we did this clinical audit with aim est...