BACKGROUND AND PURPOSE DNA damage and its repair mechanism are thought to be involved in ischemia/reperfusion injury in the brain. We have previously shown that apurinic/apyrimidinic endonuclease (APE/Ref-1), a multifunctional protein in the DNA base excision repair pathway, rapidly decreased after transient focal cerebral ischemia (FCI) before the peak of DNA fragmentation. To further investig...

Predicting the agglomeration and breakage of solid particles is important when designing a compact efficient water purification process. A coupled computational fluid dynamics model presented where population balance equation applied to track particle size distribution for periodic turbulent pipe flow with 180° bends Reynolds numbers 15,000<Ref<35,000 bend radii rB=dh,rB=1.5dh rB=2.5dh. The cri...

Deimination refers to conversion of protein-bound arginine into citrulline. An mRNA carrier, RNA binding export factor (REF), present on mitochondria undergoes loss of deimination with impaired ATP5b mRNA transport in ND4 mice (model of multiple sclerosis) compared with the controls. We present evidence of (1) reduced ATP5b mRNA binding strength of non-deiminated REF compared with deiminated RE...

Introduction As is regularly noted, CSCW is an inherently interdisciplinary field, bringing together a diverse range of sociologists, psychologists, designers, engineers, computer scientists, organizational theorists, and more. Successful research in CSCW typically requires incorporating different perspectives and understanding the mutual implications of different approaches to understanding co...

Q1 Please confirm that given names and surnames have been identified correctly. Q2 Ref. 20 is cited in the text but not provided in the reference list. Please provide it in the reference list or delete the citation from the text. Q3 Please check the journal title in ref. 1, and correct if necessary. Q4 Please check the abbreviated journal title in ref. 8, and correct if necessary. Q5 Please pro...

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main source(s): This research is supported by a grant the Korea Health Technology R&amp;D Project through Industry Development Institute (KHIDI) funded Ministry &amp; Welfare and Basic Science Research Program Foundation (NRF) Education, Republic Korea. Background Doxorubicin an anthracycline anti...

With our growing understanding of the pathways involved in cell proliferation and signaling, targeted therapies, in the treatment of cancer are entering the clinical arena. New and emerging targets are proteins involved in DNA repair pathways. Inhibition of various proteins in the DNA repair pathways sensitizes cancer cells to DNA damaging agents such as chemotherapy and/or radiation. We study ...

Apurinic apyrimidinic endonuclease redox effector factor-1 (APE1/Ref-1) is involved both in the base excision repair (BER) of DNA lesions and in the eukaryotic transcriptional regulation. APE1/Ref-1 is regulated at both the transcriptional and post-translational levels, through control of subcellular localization and post-translational modification. In response to stress conditions, several cel...