OBJECTIVE To determine the predictors affecting treatment outcome after application of the mandibular advancement device (MAD). DESIGN Retrospective analysis. SETTING Tertiary care university hospital. PATIENTS A total of 76 patients (68 men and 8 women) who were treated with the MAD for obstructive sleep apnea (OSA) were included from September 2005 through August 2008. All the subjects ...

BACKGROUND Budesonide is a potent corticosteroid commonly prescribed for management of inflammation in chronic rhinosinusitis (CRS). The standard for prescribing budesonide is via impregnated nasal saline irrigation (INSI), although recently the mucosal atomization device (MAD) has emerged as a theoretically superior method of distributing medication into the sinuses. The MAD atomizes medicatio...

BACKGROUND Human immunodeficiency virus (HIV) and methamphetamine use commonly affect neurocognitive (NC) functioning. We evaluated the relationships between NC functioning and two fibroblast growth factors (FGFs) in volunteers who differed in HIV serostatus and methamphetamine dependence (MAD). METHODS A total of 100 volunteers were categorized into four groups based on HIV serostatus and MA...

Components of the signaling pathways that lie downstream of Ser/Thr kinase receptors and are required for signaling by the TGF beta superfamily have been poorly defined. The Drosophila gene Mothers against dpp (MAD) and the C. elegans sma genes are implicated in these signaling pathways. We show that MAD functions downstream of DPP receptors and is required for receptor signaling. Phosphorylati...

Computerized generation of humor is a notoriously difficult AI problem. We develop an algorithm called Libitum that helps humans generate humor in a Mad Lib R ©, which is a popular fill-in-the-blank game. The algorithm is based on a machine learned classifier that determines whether a potential fill-in word is funny in the context of the Mad Lib story. We use Amazon Mechanical Turk to create gr...

Mandibuloacral dysplasia (MAD) is a rare genetic condition characterized by bone abnormalities including localized osteolysis and generalized osteoporosis, skin pigmentation, lipodystrophic signs and mildly accelerated ageing. The molecular defects associated with MAD are mutations in LMNA or ZMPSTE24 (FACE1) gene, causing type A or type B MAD, respectively. Downstream of LMNA or ZMPSTE24 mutat...

Mad honey poisoning occurs through the intake of honey made from the nectar of Rhododendron species containing grayanotoxins, a family of lipid-soluble toxins responsible for the clinical manifestations of mad honey intoxication syndrome. These plants grow in the eastern parts of the Black Sea region of Turkey and in various other parts of the world (e.g., South America, Europe, and Japan). Pre...

Study of the normalizer of the MAD-group corresponding to a fine grading offers the most important tool for describing symmetries in the system of non-linear equations connected with contraction of a Lie algebra. One fine grading that is always present in any Lie algebra sl(n, C) is the Pauli grading. The MAD-group corresponding to it is generated by generalized Pauli matrices. For such MAD-gro...