Anniversary This year marks a milestone for Clinical Cancer Research (CCR)—we are celebrating our 20 th anniversary. CCR was launched in January 1995 by the American Association for Cancer Research (AACR), and at the time it was the third journal to join AACR's family of publications (following Cancer Research and Cancer Epidemiology, Biomarkers & Prevention). The journal was launched to report...

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BACKGROUND Although endogenous creatinine clearance is often used as an indicator for the glomerular filtration rate (GFR), it may result in an overestimation due to its tubular secretion. Since cimetidine is known to inhibit tubular secretion of creatinine, it may improve the accuracy of the creatinine clearance in measuring GFR. METHODS Creatinine clearance (Ccr) was compared with iothalama...

It has been shown that certain chemokine receptor polymorphisms may correspond to certain complications after organ transplantation. Ischemic-type biliary lesion (ITBL) encounters for major morbidity and mortality in liver transplant recipients. So far, the exact cause for ITBL remains unclear. Certain risk factors for the development of ITBL like donor age and cold ischemic time are well descr...

Cyclocreatine (CCr), a substrate analogue of creatine kinase (CK), exhibits antitumor activity in vitro and in vivo. To address its mechanism of action, we have examined its effects on tumor cell proliferation, viabil ity, and cell cycle progression. Complete inhibition of proliferation of ME-iSO cervical carcinoma cells was observed within S h of exposure to CCr and was characterized by an inh...

OBJECTIVE In view of the previously described anti-inflammatory effects of insulin, we investigated the potential suppressive effect of insulin on plasma concentrations and expression of the chemokines, monocyte chemoattractant protein-1 (MCP-1) and regulated on activation normal T-cell expressed and secreted (RANTES) and their receptors, chemokine receptor (CCR)-2 and CCR-5, in mononuclear cel...

Optical sensors for detecting temperature and strain play a crucial role in the analysis of environmental conditions and real-time remote sensing. However, the development of a single optical device that can sense temperature and strain simultaneously remains a challenge. Here, a flexible corner cube retroreflector (CCR) array based on passive dual optical sensing (temperature and strain) is de...

Renal clearance function and urinary albumin excretion are important markers for diabetic nephropathy. We assessed whether the creatinine clearance rate (CCR) and daily urinary albumin (DUA) excretion, which both require 24-hour urine data, are better predictors of mortality in diabetic inpatients compared with the estimated glomerular filtration rate (eGFR) and urine albumin-creatinine ratio (...

In many bacteria glucose is the preferred carbon source and represses the utilization of secondary substrates. In Bacillus subtilis, this carbon catabolite repression (CCR) is achieved by the global transcription regulator CcpA, whose activity is triggered by the availability of its phosphorylated cofactors, HPr(Ser46-P) and Crh(Ser46-P). Phosphorylation of these proteins is catalyzed by the me...

Com o avanço da tecnologia nos últimos anos a inteligência artificial (IA) foi desenvolvida com objetivo de realizar tarefas que se assemelhem ao comportamento humano racional através do aprendizado profundo e máquinas. A associação IA gastroenterologia visa favorecer identificação lesões precursoras câncer colorretal (CCR). nível mundial CCR é terceira neoplasia mais prevalente quarta causa ób...