This paper considers the acknowledgment procedure used to assure the delivery of packets on the radio interface of General Packet Radio Service (GPRS), where GPRS system is a new GSM service. It is currently being standardized for GSM Phase 2+ and provides packet switched data services over GSM network resources. This paper gives a rapid description of the GPRS radio interface, and its sublayer...

We study the problem of determining the switching patterns and switching times of multiple aggressors to generate the worst-case crosstalk noise (WCN) for a quiet victim in RLC interconnect structures under the constraints of both aggressor switching windows and the victim sampling window. We consider the signal routing direction and show that it has a significant impact under RLC model but not...

The effects of inductance on repeater insertion in RLC trees is the focus of this paper. An algorithm is introduced to insert and size repeaters within an RLC tree to optimize a variety of possible cost functions such as minimizing the maximum path delay, the skew between branches, or a combination of area, power, and delay. The algorithm has a complexity proportional to the square of the numbe...

Familial hypertrophic cardiomyopathy (FHC) is caused by mutations in sarcomeric proteins including the myosin regulatory light chain (RLC). Two such FHC mutations, R58Q and N47K, located near the cationic binding site of the RLC, have been identified from population studies. To examine the molecular basis for the observed phenotypes, we exchanged endogenous RLC from native porcine cardiac myosi...

We have determined the 2.3-Å-resolution crystal structure of a myosin light chain domain, corresponding to one type found in sea scallop catch ("smooth") muscle. This structure reveals hinges that may function in the "on" and "off" states of myosin. The molecule adopts two different conformations about the heavy chain "hook" and regulatory light chain (RLC) helix D. This conformational change r...

We have performed complementary time-resolved fluorescence resonance energy transfer (TR-FRET) experiments and molecular dynamics (MD) simulations to elucidate structural changes in the phosphorylation domain (PD) of smooth muscle regulatory light chain (RLC) bound to myosin. PD is absent in crystal structures, leaving uncertainty about the mechanism of regulation. Donor-acceptor pairs of probe...

Mutant Dictyostelium cells lacking any of the component polypeptides of myosin II exhibit developmental defects. To define myosin's role in establishing Dictyostelium's developmental pattern, we have rescued myosin function in a myosin regulatory light chain null mutant (mlcR-) using cell-type-specific promoters. While mlcR- cells fail to progress beyond the mound stage, expression of RLC from ...

With the increase in frequency towards the giga hertz range, the analysis of high frequency effects like skin effect etc. are becoming extensively predominant and important for high speed VLSI design. Skin effect attenuates the high frequency components of a signal more than that of the low frequency components. Noise produced in any interconnect segment may degrade the performance of the entir...

The aim of this paper is to give a formulation of the dynamics of nonlinear RLC circuits as a geometric Birkhoffian system and to discuss in this context the concepts of regularity, conservativeness, dissipativeness. An RLC circuit, with no assumptions placed on its topology, will be described by a family of Birkhoffian systems, parameterized by a finite number of real constants which correspon...

Ca(2+)/calmodulin (CaM)-dependent phosphorylation of myosin regulatory light chain (RLC) by myosin light chain kinase (MLCK) initiates smooth muscle contraction and regulates actomyosin-based cytoskeletal functions in nonmuscle cells. The net extent of RLC phosphorylation is controlled by MLCK activity relative to myosin light chain phosphatase activity. We have constructed a CaM-sensor MLCK wh...