OBJECTIVE Pepducins are membrane-tethered, cell-penetrating lipopeptides that target the cytoplasmic surface of their cognate receptor. Here, we report the first human use of a protease-activated receptor-1-based pepducin, which is intended as an antiplatelet agent to prevent ischemic complications of percutaneous coronary interventions. APPROACH AND RESULTS PZ-128 was administered by 1 to 2 ...

PURPOSE To retrospectively determine the accuracy of diffusion-weighted (DW) magnetic resonance (MR) imaging for identifying cancer in the prostate peripheral zone (PZ) and to assess the accuracy of tumor volume measurements made with T2-weighted imaging and combined T2-weighted and DW MR imaging by using surgical pathologic examination as the reference standard. MATERIALS AND METHODS The ins...

We show that if p is prime and A is a sum-free subset of Z/pZ with n := |A| > 0.33p, then A is contained in a dilation of the interval [n, p−n] (mod p).

In this work, a photocatalytic nanocomposite, Fe-doped ZnO/nanocellulose, was synthesized using an in-situ method and examined for methylene blue (MB) degradation. For purpose, pure ZnO (PZ) by the chemical precipitation then subjected to Fe+3 doping with different concentrations of Fe3+ (1, 3, 5 mol%). The PZ (FZ) samples were characterized several standard analyses. UV–Vis DRS analysis also u...

Carbon dioxide emissions are the largest greenhouse gases contributor, which is attributed to global warming. Therefore, capture of CO2 necessary, especially from large point sources. Post-combustion using chemical solvents most matured technology. In this paper, mixed methyldiethanolamine (MDEA) and piperazine (PZ) were studied potentially address some issues related use conventional monoethan...

Two-photon annihilate contributions in the process e + e− → p+ p̄ including N and ∆ intermediate are discussed in a simple hadronic model. The corrections to the unpolarized cross section and polarized observables Px, Pz are presented. The results show the two-photon annihilate correction to unpolarized cross section is small and its angle dependence becomes weak at small s after considering the...

The secretion of trypsin and chymotrypsin into the duodenum in response to secretin and CCK-PZ has been compared with the faecal excretion of the enzymes following similar stimulation in 47 individuals undergoing clinical investigation. The faecal output of chymotrypsin correlated well, but trypsin less satisfactorily, with the secretion of the respective enzymes into the duodenum. The faecal e...