نتایج جستجو برای: ماهوارة irs
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در این مقاله به مدل‌سازی تغییرات جزرومدی سطح آب دریای عمان و خلیج فارس با استفاده از 11 سال داده‌های ماهوارة توپکس-پوزایدون (TOPEX/Poseidon) و اطلاعات تایدگیج‌های ساحلی پرداخته شده است. مشاهدات ماهوارة توپکس-پوزایدون در سایکل 100 مبنا در نظر گرفته شده و از تکرار مشاهدات ماهوارة توپکس-پوزایدون در اطراف مشاهدات این سایکل در شعاع 1 کیلومتری، سری زمانی با فاصلة نمونه‌برداری دو ساعته که از مشاهدات 9...
Insulin receptor substrates (IRSs) play central roles in insulin/insulin-like growth factor (IGF) signaling and mediate a variety of their bioactivities. IRSs are tyrosine-phosphorylated by activated insulin receptor/IGF-I receptor tyrosine kinase in response to insulin/IGF, and are recognized by signaling molecules possessing the SH2 domain such as phosphatidylinositol 3-kinase (PI3K), leading...
Glucose-6-phosphatase catalyzes the terminal step in the gluconeogenic and glycogenolytic pathways. In HepG2 cells, the maximum repression of basal glucose-6-phosphatase catalytic subunit (G6Pase) gene transcription by insulin requires two distinct promoter regions, designated A (located between -231 and -199) and B (located between -198 and -159), that together form an insulin response unit. R...
Serine and threonine phosphorylation of IRS-1 (insulin receptor substrate-1) has been reported to decrease its ability to be tyrosine-phosphorylated by the insulin receptor. Insulin itself may negatively regulate tyrosine phosphorylation of IRS-1 through a PI3K (phosphoinositide 3-kinase)-dependent feedback pathway. In the present study, we examined the regulation and role of IRS-1 serine phosp...
The Arg insulin receptor substrate-1 (IRS-1) variant has been hypothesized to play a role in pancreatic -cell stimulus-coupled insulin secretion and survival. We analyzed the relations between type 1 diabetes and the Arg IRS-1 variant. The frequency of the IRS-1 Arg variant was investigated in two independent sets of unrelated patients: a case-control study and a collection of type 1 diabetes s...
Intelligent reflecting surface (IRS) is a rapidly emerging paradigm to enable non-line-of-sight (NLoS) wireless transmission. In this paper, we focus on IRS-aided radar estimation performance of moving hidden or NLoS target. Unlike prior works that employ single IRS, investigate problem using multiple IRS platforms and assess the by deriving associated Cramér-Rao lower bound (CRLB). We then des...
BACKGROUND To assess frequency and distribution of infusion reactions (IRs) in responders and nonresponders in randomized clinical trials (RCTs) of intravenous pegloticase and the utility of the National Institute of Allergy and Infectious Disease/Food and Allergy and Anaphylaxis Network (NIAID/FAAN) criteria for identifying anaphylaxis in subjects experiencing IRs. METHODS IRs from two RCTs ...
OBJECTIVE Cellular stress and proinflammatory cytokines induce phosphorylation of insulin receptor substrate (IRS) proteins at Ser sites that inhibit insulin and IGF-1 signaling. Here, we examined the role of Ser phosphorylation of IRS-2 in mediating the inhibitory effects of proinflammatory cytokines and cellular stress on beta-cell function. RESEARCH DESIGN AND METHODS Five potential inhibi...
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