Background: Previously, we showed that AG2034, an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT) in the pathway for de novo purine synthesis, is cytotoxic to different prostate cancer cell lines in the absence of inosine and hypoxanthine in the culture media. Therefore, we examined DU145 androgenindependent prostate cancer cells selected for drug resistance over a prolonged p...

Background: Radiotherapy is an established therapeutic modality for prostate cancer. Resveratrol, a natural antioxidant, has been shown to inhibit carcinogenesis and to block the process of tumor initiation and progression. No data is available on the response of cellular spheroid to Reseveratol. In this study we have examined the effect of Resveratol on the radiation response of human p...

  Background: Prostate cancer is one of the leading causes of cancer deaths among men. New gene expressed in prostate (NGEP), is a prostate-specific gene expressed only in normal prostate and prostate cancer tissue. Because of its selective expression in prostate cancer cell surface, NGEP is a potential immunotherapeutic target. To target the NGEP in prostate cancer, it is essential to investig...

background: radiotherapy is an established therapeutic modality for prostate cancer. resveratrol, a natural antioxidant, has been shown to inhibit carcinogenesis and to block the process of tumor initiation and progression. no data is available on the response of cellular spheroid to reseveratol. in this study we have examined the effect of resveratol on the radiation response of human prostate...

background: the purpose of this study was to investigate the enhanced thermal resistance mechanism of the du145 tumor spheroid cultures as compared to the prostate carcinoma cell line's monolayer cultures. materials and methods: du145 cells were cultured either as spheroids or monolayers. cultures were treated with hyperthermia in a precision water bath (at 43°c for 60 minutes) and/or quercetin...