This study addressed several questions relating to the core features of Tourette syndrome (TS) including in particular coprolalia (involuntary utterance of obscene words) and copropraxia (involuntary and inappropriate rude gesturing). A cohort of 400 TS patients was investigated. We observed that coprolalia occurred in 39% of the full cohort of 400 patients and copropraxia occurred in 20% of th...

This work examines the use of new hydrophobic ionic liquid derivatives, namely octadecylammonium tosylate (ODA-TS) and oleylammonium tosylate (OA-TS) for corrosion protection of steel in 1 M hydrochloric acid solution. Their chemical structures were determined from NMR analyses. The surface activity characteristics of the prepared ODA-TS and OA-TS were evaluated from conductance, surface tensio...

Tourette syndrome (TS) is a neurodevelopmental disorder with a rich phenomenology that includes simple and complex motor and vocal tics as well as multiple comorbidities. From a nosological perspective, it is evident that a continuum of tic severity exists, of which TS is the most severe and rare form, while transient tics and chronic tics represent milder forms. From a psychopathology perspect...

هدف: این پژوهش با هدف ارائه مدل چالش‌های پرورش کودکان کم‌شنوای پیش‌دبستانی از دیدگاه مادران و متخصصان بر اساس نظریه داده‌بنیاد انجام ‌شده است. روش: نمونه 15 مادر کودک کم‌شنوا 4 تا 6 ساله انجمن والدین شهر تهران 5 متخصص حوزه ناشنوا بودند که در سال 1400 استفاده روش نمونه‌گیری هدفمند انتخاب شدند. چالش ­های طریق مصاحبه نیمه ساختاریافته عمیق رسیدن به اشباع نظری جمع‌آوری کدگذاری (کدگذاری باز، محوری ان...

هدف: پژوهش حاضر با هدف شناسایی پیامدهای تحمل ابهام رهبران و طراحی الگوی جامعی از این پیامدها صورت ­گرفته ­است.طراحی/ روش‌شناسی/ رویکرد: رویکرد کیفی روش تحلیل­ مضمون انجام­ شده­ است. جامعه­ آماری عبارتند خبرگان دانشگاهی اجرایی وزارت نفت که تجربه تصمیم‌­گیری مدیریت در شرایط عدم اطمینان را دارند. نمونه نوزده نفر بوده ­است. نمونه‌­گیری پژوهش، هدفمند گلوله‌برفی انجام ­شد. داده‌ها نیز طریق مصاحبه گرد...

Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...

Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...

Thymidylate synthase (TS) (EC 2.1.1.45) is an important cellular target for the fluoropyrimidine cytotoxic drugs that are widely used in the treatment of solid tumors. Using the TS 106 monoclonal antibody to human TS, we have compared the immunological quantitation of TS by Western immunoblot and immunofluorescent techniques to the conventional biochemical 5-fluorodeoxyuridine monophosphate bin...

Folate analogues that inhibit thymidylate synthase (TS) selectively were developed based on TS and folate molecular structures and properties. The structure-activity relationship, preclinical and clinical development, and issues of potential importance in the future success of these TS inhibitors are reviewed herein. Properties of these new compounds depend mainly on the use of the reduced fola...

Thymidylate synthase (TS) is essential in thymidylate biosynthesis and DNA replication. Dihydropyrimidine dehydrogenase (DPD) is a rate-limiting enzyme in pyrimidine catabolism and is important in catabolism of 5-fluorouracil (5-FU). The significance of TS and DPD expressed in lung cancer remains controversial. Here we analyzed the relationship between TS and DPD expression and clinicopathologi...