Purpose Prospective treatments for age-related macular degeneration and inherited retinal degenerations are commonly evaluated in the Royal College of Surgeons (RCS) rat before translation into clinical application. Historically, retinal thickness obtained through postmortem anatomic assessments has been a key outcome measure; however, utility of this measurement is limited because it precludes...

PURPOSE The aim of this study was to identify whether abnormalities in the synthesis of basic fibroblast growth factor (bFGF) or its receptor (bFGF-R) were responsible for the photoreceptor dystrophy in Royal College of Surgeons (RCS) rats. METHODS The polymerase chain reaction was used to detect the expression of bFGF and bFGF-R messenger RNA in the retinal pigment epithelial (RPE) cells and...

We use both frequency- and time-domain low-temperature (5-20 K) spectroscopies to further elucidate the shape and spectral position of singlet minus triplet (triplet-bottleneck) spectra in the reaction centers (RCs) of Photosystem II (PSII) isolated from wild-type Chlamydomonas reinhardtii and spinach. It is shown that the shape of the nonresonant transient hole-burned spectrum in destabilized ...

Composite RCS building frames integrate reinforced concrete columns with structural steel beams to provide an efficient solution for the design and construction of earthquake-resisting structures. In this paper, an optimization framework is developed for performance-based seismic design of planar RCS moment resisting frames. The objective functions are defined as minimizing the construction cos...

The National Institute of Standards and Technology (NIST) has been developing the \Real-Time Control Systems (RCS)" software for more than two decades and using it for the design and implementation of complex intelligent control systems. Present applications of RCS include mining, manufacturing, robotics, and autonomous vehicles. In this paper we summarize the e orts at Ohio State University to...

in turn affects the physical, psychological, social and economical well being of some of the leprosy afflicted persons (LAPs). To prevent and correct deformities Government of India has focused on early diagnosis and appropriate treatment. In addition government has been providing services of Reconstructive Surgery (RCS). RCS corrects the deformity and is expected to help in reducing the stigma...

PURPOSE The authors investigated intercellular communication among cultured rat retinal pigment epithelial (RPE) cells isolated from dystrophic Royal College of Surgeons (RCS) rats by studying the conduction of the [Ca2+]i wave elicited by mechanical stimulation. The effect of protein phosphorylation was measured by modulating the protein kinase C (PKC), protein kinase A (PKA), and tyrosine kin...